ArticleMechanisms of development
PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation.
Article in Mechanisms of development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 22 citations in OpenAlex.
- Identification of the Crucial Gene in Overflow Arteriovenous Fistula by Bioinformatics Analysis.Frontiers in physiology · 2021Article
- A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.Frontiers in physiology · 2019Article
- Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells.Scientific reports · 2018Article
- Inferring Intracellular Signal Transduction Circuitry from Molecular Perturbation Experiments.Bulletin of mathematical biology · 2018Article
- Article
- Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencing.Developmental biology · 2017Article
- Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants.BMC biology · 2016Article
- The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organization.Developmental biology · 2012Article
- ErbB/EGF signaling and EMT in mammary development and breast cancer.Journal of mammary gland biology and neoplasia · 2010Review
- Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization.BMC developmental biology · 2009Article
- The role of NRG3 in mammary development.Journal of mammary gland biology and neoplasia · 2008Review
- Xenopus ADAM19 is involved in neural, neural crest and muscle development.Mechanisms of developmentArticle
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2 authors at 1 institution in 1 country.
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Abstract
ErbB signaling regulates cell adhesion and movements during Xenopus gastrulation, but the downstream pathways involved have not been elucidated. In this study, we show that phosphatidylinositol-3 kinase (PI3K) and Erk mitogen-activated protein kinase (MAPK) mediate ErbB signaling to regulate gastrulation. Both PI3K and MAPK function sequentially in mesoderm specification and movements, and ErbB signaling is important only for the late phase activation of these pathways to control cell behaviors. Activation of either PI3K or Erk MAPK rescues gastrulation defects in ErbB4 morphant embryos, and restores convergent extension in the trunk mesoderm as well as coherent cell migration in the head mesoderm. The two signals preferentially regulate different aspects of cell behaviors, with PI3K more efficient in rescuing cell adhesion and spreading and MAPK more effective in stimulating the formation of filopodia. PI3K and MAPK also weakly activate each other, and together they modulate gastrulation movements. Our results reveal that PI3K and Erk MAPK, which have previously been considered as mesodermal inducing signals, also act downstream of ErbB signaling to participate in regulation of gastrulation morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.