ArticleHearing research2007
Closure of supporting cell scar formations requires dynamic actin mechanisms.
Article in Hearing research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Some Ototoxic Drugs Destroy Cochlear Support Cells Before Damaging Sensory Hair Cells.Neurotoxicity research · 2020Article
- Non-autonomous Cellular Responses to Ototoxic Drug-Induced Stress and Death.Frontiers in cellular neuroscience · 2017Review
- Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells.PloS one · 2016Article
- Live imaging the phagocytic activity of inner ear supporting cells in response to hair cell death.Cell death and differentiation · 2015Article
- Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle.Frontiers in cellular neuroscience · 2015Article
- How to bury the dead: elimination of apoptotic hair cells from the hearing organ of the mouse.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Recovery of otoacoustic emissions after high-level noise exposure in the American bullfrog.The Journal of experimental biology · 2014Article
- Responses to cell loss become restricted as the supporting cells in mammalian vestibular organs grow thick junctional actin bands that develop high stability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Lead roles for supporting actors: critical functions of inner ear supporting cells.Hearing research · 2013Review
- Changes in the adult vertebrate auditory sensory epithelium after trauma.Hearing research · 2013Review
- Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood.Scientific reports · 2012Article
- Intracellular mechanisms of aminoglycoside-induced cytotoxicity.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.American journal of human genetics · 2009Article
- Recent advances in hair cell regeneration research.Current opinion in otolaryngology & head and neck surgery · 2008Review
- Damage-induced activation of ERK1/2 in cochlear supporting cells is a hair cell death-promoting signal that depends on extracellular ATP and calcium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Genetic and pharmacological intervention for treatment/prevention of hearing loss.Journal of communication disordersReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In many vertebrate inner ear sensory epithelia, dying sensory hair cells are extruded, and the apices of surrounding supporting cells converge to re-seal the epithelial barrier between the electrochemically-distinct endolymph and perilymph. These cellular mechanisms remain poorly understood. Dynamic microtubular mechanisms have been proposed for hair cell extrusion; while contractile actomyosin-based mechanisms are required for cellular extrusion and closure in epithelial monolayers. The hypothesis that cytoskeletal mechanisms are required for hair cell extrusion and supporting cell scar formation was tested using bullfrog saccules incubated with gentamicin (6h), and allowed to recover (18h). Explants were then fixed, labeled for actin and cytokeratins, and viewed with confocal microscopy. To block dynamic cytoskeletal processes, disruption agents for microtubules (colchicine, paclitaxel) myosin (Y-27632, ML-9) or actin (cytochalasin D, latrunculin A) were added during treatment and recovery. Microtubule disruption agents had no effect on hair cell extrusion or supporting cell scar formation. Myosin disruption agents appeared to slow down scar formation but not hair cell extrusion. Actin disruption agents blocked scar formation, and largely prevented hair cell extrusion. These data suggest that actin-based cytoskeletal processes are required for hair cell extrusion and supporting cell scar formation in bullfrog saccules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.