ArticleJournal of neuroscience methods2007
Measurement of contractile force of skeletal and extraocular muscles: effects of blood supply, muscle size and in situ or in vitro preparation.
Article in Journal of neuroscience methods, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Assessing expert reliability in determining intracranial EEG channel quality and introducing the automated bad channel detection algorithm.Journal of neural engineering · 2024Article
- Measurement of Murine Neuromuscular Function Using the In Situ Preparation.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Cytoskeletal Proteins in Myotendinous Junctions of Human Extraocular Muscles.Investigative ophthalmology & visual science · 2021Article
- Repairing Volumetric Muscle Loss in the Ovine Peroneus Tertius Following a 3-Month Recovery.Tissue engineering. Part A · 2020Article
- Distance between intramuscular nerve and artery in the extraocular muscles: a preliminary immunohistochemical study using elderly human cadavers.Surgical and radiologic anatomy : SRA · 2017Article
- The effects of bupivacaine injection and oral nitric oxide on extraocular muscle in the rabbit.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2013Article
- How to make rapid eye movements "rapid": the role of growth factors for muscle contractile properties.Pflugers Archiv : European journal of physiology · 2011Article
- Insulin-like growth factor-1 and cardiotrophin 1 increase strength and mass of extraocular muscle in juvenile chicken.Investigative ophthalmology & visual science · 2010Article
- The viscoelastic properties of passive eye muscle in primates. I: static forces and step responses.PloS one · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Contractile forces can be measured in situ and in vitro. To maintain metabolic viability with sufficient diffusion of oxygen, established guidelines for in vitro skeletal muscle preparations recommend use of relatively thin muscles (< or =1.25 mm thick). Nevertheless, forces of thin extraocular muscles vary substantially between studies. Here, we examined parameters that affect force measurements of in situ and in vitro preparations, including blood supply, nerve stimulation, direct muscle stimulation, muscle size, oxygenated or non-oxygenated buffer solutions and the time after interruption of vascular circulation. We found that the absolute forces of extraocular muscle are substantially lower when examined in vitro. In vitro preparation of 0.58 mm thick extraocular muscle from 3-week-old birds underestimated contractile function, but not of thinner (0.33 mm) muscle from 2-day-old birds. Our study shows that the effective criteria for functional viability, tested in vitro, differ between extraocular and other skeletal muscle. We conclude that contractile force of extraocular muscles will be underestimated by between 10 and 80%, when measurements are made after cessation of blood supply (at 5-40 min). The mechanisms responsible for the declining values for force measurements are discussed, and we make specific recommendations for obtaining valid measurements of contractile force.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.