ArticleCell calcium2008
Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging.
Article in Cell calcium, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- KRAP tethers IPNature communications · 2021Article
- Picomolar sensitivity to inositol trisphosphate in Xenopus oocytes.Cell calcium · 2015Article
- High frame-rate multichannel beam-scanning microscopy based on Lissajous trajectories.Optics express · 2014Article
- Article
- Cooperative and stochastic calcium releases from multiple calcium puff sites generate calcium microdomains in intact Hela cells.The Journal of biological chemistry · 2012Article
- Termination of Ca²+ release for clustered IP₃R channels.PLoS computational biology · 2012Article
- Signal mass and Ca²⁺ kinetics in local calcium events: a modeling study.Journal of molecular modeling · 2012Article
- Inositol (1,4,5)-trisphosphate receptor microarchitecture shapes Ca2+ puff kinetics.Biophysical journal · 2011Article
- IP(3) receptors: toward understanding their activation.Cold Spring Harbor perspectives in biology · 2010Review
- Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp.The Journal of general physiology · 2010Article
- Superresolution localization of single functional IP3R channels utilizing Ca2+ flux as a readout.Biophysical journal · 2010Article
- Calcium domains around single and clustered IP3 receptors and their modulation by buffers.Biophysical journal · 2010Article
- Calcium signaling and amyloid toxicity in Alzheimer disease.The Journal of biological chemistry · 2010Review
- Localization and socialization: experimental insights into the functional architecture of IP3 receptors.Chaos (Woodbury, N.Y.) · 2009Review
- Modeling of the modulation by buffers of Ca2+ release through clusters of IP3 receptors.Biophysical journal · 2009Article
- Synaptic activation and membrane potential changes modulate the frequency of spontaneous elementary Ca2+ release events in the dendrites of pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Article
- Nuclear pore disassembly from endoplasmic reticulum membranes promotes Ca2+ signalling competency.The Journal of physiology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Elementary events such as puffs and sparks are cytosolic microdomains of Ca2+ from which cellular Ca2+ signals are constructed. Because of the tight localization and fast kinetics of elementary events, imaging studies have been hindered by instrumental limitations of confocal and deconvolution fluorescence microscopy which necessitate compromises between spatial and temporal resolution. Here, we describe a novel, yet simple 'multi-focal' fluorescence microscopy system that employs three high-speed cameras focused at different axial depths to enable 4-dimensional imaging with millisecond resolution. We demonstrate the utility of this system for studies of puffs in Xenopus oocytes by mapping the axial distribution of puff sites, by obtaining measurements of puff amplitudes undistorted by focus error, and by deriving deblurred images that reveal novel sub-micron jumps of Ca2+ release sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.