ArticleVirology2007
Human cytomegalovirus and human immunodeficiency virus type-1 co-infection in human cervical tissue.
Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Double trouble: how co- and superinfections shape viral dynamics and host responses.Journal of virology · 2026Review
- Article
- Ginkgolic acid inhibits fusion of enveloped viruses.Scientific reports · 2020Article
- Latent human cytomegalovirus enhances HIV-1 infection in CD34Blood advances · 2017Article
- Imaging and tracking HIV viruses in human cervical mucus.Journal of biomedical optics · 2016Article
- In vitro antiretroviral activity and in vivo toxicity of the potential topical microbicide copper phthalocyanine sulfate.Virology journal · 2015Article
- Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides.Science translational medicine · 2014Article
- Evaluation of cervical mucosa in transmission bottleneck during acute HIV-1 infection using a cervical tissue-based organ culture.PloS one · 2012Article
- Modeling of human cytomegalovirus maternal-fetal transmission in a novel decidual organ culture.Journal of virology · 2011Article
- Mechanisms of viral infections associated with HIV: workshop 2B.Advances in dental research · 2011Article
- Cervico-vaginal tissue ex vivo as a model to study early events in HIV-1 infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Article
- Clinical parameters essential to methodology and interpretation of mucosal responses.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Review
- Multisite comparison of anti-human immunodeficiency virus microbicide activity in explant assays using a novel endpoint analysis.Journal of clinical microbiology · 2009Article
- Movements of HIV-virions in human cervical mucus.Biomacromolecules · 2009Article
- Use of human tissue explants to study human infectious agents.Nature protocols · 2009Article
- Determinants of HIV shedding in the lower genital tract of women.Current infectious disease reports · 2008Article
- Differential inhibition of human cytomegalovirus (HCMV) by toll-like receptor ligands mediated by interferon-beta in human foreskin fibroblasts and cervical tissue.Virology journal · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Human cytomegalovirus (HCMV) and human immunodeficiency virus type-1 (HIV-1) infect the female genital tract. A human cervical explant model was developed to study single and dual infection by these viruses in the genital compartment. An HCMV strain expressing green fluorescent protein, and two clinical HCMV strains produced peak viral DNA copies at 14 to 21 days post-infection. Peak levels of HIV-1(Ba-L) p24 antigen occurred at 7 days post-infection. HIV-1(Ba-L) appeared to enhance HCMV in co-infected tissues. Singly and dually infected explants produced increased levels of cytokines IL-6, IL-8, and GRO-alpha in culture supernatants. Immunohistochemical and flow cytometric analysis showed HCMV infection of leukocytes with the phenotype CD45+/CD1a+/CD14+/HLA-DR+ but not stromal or endothelial cells. Cells expressing both GFP and HIV-1 p24 antigen were detected in co-infected tissues. The cervical explants provide an ex vivo human model for examining mechanisms of virus-virus interaction and pathogenesis in clinically relevant tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.