ArticlePhysiology & behavior2007
Effects of anabolic androgenic steroids on the development and expression of running wheel activity and circadian rhythms in male rats.
Article in Physiology & behavior, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
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- Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine.Neuroscience and biobehavioral reviews · 2024Review
- Sex differences in daily timekeeping and circadian clock circuits.Seminars in cell & developmental biology · 2022Review
- Sex Hormone Suppression and Physical Activity: Possible Implications for Transgender Individuals.Transgender health · 2022Article
- An update on adolescent sleep: New evidence informing the perfect storm model.Journal of adolescence · 2018Review
- Differential Sensitivity to Ethanol-Induced Circadian Rhythm Disruption in Adolescent and Adult Mice.Alcoholism, clinical and experimental research · 2017Article
- Androgen Modulation of Hippocampal Structure and Function.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2016Review
- Mad men, women and steroid cocktails: a review of the impact of sex and other factors on anabolic androgenic steroids effects on affective behaviors.Psychopharmacology · 2016Review
- Article
- Estrogens, androgens and generalized behavioral arousal in gonadectomized female and male C57BL/6 mice.Physiology & behavior · 2015Article
- The impact of nandrolone decanoate on the central nervous system.Current neuropharmacology · 2015Review
- Sex and exercise interact to alter the expression of anabolic androgenic steroid-induced anxiety-like behaviors in the mouse.Hormones and behavior · 2014Article
- Sex differences in behavioral circadian rhythms in laboratory rodents.Frontiers in endocrinology · 2014Review
- Nuclear receptor coactivators: regulators of steroid action in brain and behaviour.Journal of neuroendocrinology · 2013Review
- Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Adolescent sleep patterns in humans and laboratory animals.Hormones and behavior · 2013Review
- The neuroendocrine control of the circadian system: adolescent chronotype.Frontiers in neuroendocrinology · 2012Review
- Convergence of multiple mechanisms of steroid hormone action.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2012Review
- Steroid receptor coactivator 2 modulates steroid-dependent male sexual behavior and neuroplasticity in Japanese quail (Coturnix japonica).Journal of neurochemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
In humans, anabolic androgenic steroid (AAS) use has been associated with hyperactivity and disruption of circadian rhythmicity. We used an animal model to determine the impact of AAS on the development and expression of circadian function. Beginning on day 68 gonadally intact male rats received testosterone, nandrolone, or stanozolol via constant release pellets for 60 days; gonadally intact controls received vehicle pellets. Wheel running was recorded in a 12:12 LD cycle and constant dim red light (RR) before and after AAS implants. Post-AAS implant, circadian activity phase, period and mean level of wheel running wheel activity were compared to baseline measures. Post-AAS phase response to a light pulse at circadian time 15 h was also tested. To determine if AAS differentially affects steroid receptor coactivator (SRC) expression we measured SRC-1 and SRC-2 protein in brain. Running wheel activity was significantly elevated by testosterone, significantly depressed by nandrolone, and unaffected by stanozolol. None of the AAS altered measures of circadian rhythmicity or phase response. While SRC-1 was unaffected by AAS exposure, SRC-2 was decreased by testosterone in the hypothalamus. Activity levels, phase of peak activity and circadian period all changed over the course of development from puberty to adulthood. Development of activity was clearly modified by AAS exposure as testosterone significantly elevated activity levels and nandrolone significantly suppressed activity relative to controls. Thus, AAS exposure differentially affects both the magnitude and direction of developmental changes in activity levels depending in part on the chemical composition of the AAS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.