ArticleReproductive biology and endocrinology : RB&E2007
Genomic and proteomic profiling I: leiomyomas in African Americans and Caucasians.
Article in Reproductive biology and endocrinology : RB&E, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Racial disparities in uterine fibroids and endometriosis: a systematic review and application of social, structural, and political context.Fertility and sterility · 2023Pooled it
- Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation.Pharmacological research · 2021Trial
- Racial disparities and risk factors for blood transfusion in patients undergoing myomectomy for uterine fibroids: insights from a national surgical database.Facts, views & vision in ObGyn · 2026Article
- Mechanical Stiffness Influences the Response of Human Uterine Fibroid Cells to Hormonal Treatments.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Uterine Stroma-Derived Tumors and the Extracellular Matrix: A Comparative Review of Benign and Malignant Pathologies.Cancers · 2025Review
- The Influence of Race/Ethnicity on the Transcriptomic Landscape of Uterine Fibroids.International journal of molecular sciences · 2023Article
- Transcriptome and DNA methylome analyses reveal underlying mechanisms for the racial disparity in uterine fibroids.JCI insight · 2022Article
- Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Epigenomic and enhancer dysregulation in uterine leiomyomas.Human reproduction update · 2022Review
- Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata.Cancer genetics · 2018Article
- The health disparities of uterine fibroid tumors for African American women: a public health issue.American journal of obstetrics and gynecology · 2014Review
- The burden of uterine fibroids for African-American women: results of a national survey.Journal of women's health (2002) · 2013Article
- Racial and ethnic differences in the pathogenesis and clinical manifestations of uterine leiomyoma.Seminars in reproductive medicine · 2013Article
- Relationship between hysterectomy and admixture in African American women.American journal of obstetrics and gynecology · 2013Article
- Validation of the aging hen (Gallus gallus domesticus) as an animal model for uterine leiomyomas.Biology of reproduction · 2012Article
- Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances.Journal of assisted reproduction and genetics · 2012Review
- miR-93/106b and their host gene, MCM7, are differentially expressed in leiomyomas and functionally target F3 and IL-8.Molecular endocrinology (Baltimore, Md.) · 2012Article
- A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells.Experimental & molecular medicine · 2012Article
- Uterine leiomyomas: individualizing the approach to a heterogeneous condition.Obstetrics and gynecology · 2011Review
- Expression profile of microRNAs and mRNAs in human placentas from pregnancies complicated by preeclampsia and preterm labor.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundClinical observations indicate that leiomyomas occur more frequently in African Americans compared to other ethnic groups with unknown etiology. To identify the molecular basis for the difference we compared leiomyomas form A. Americans with Caucasians using genomic and proteomic strategies.
methodsMicroarray, realtime PCR, 2D-PAGE, mass spectrometry, Western blotting and immunohistochemistry.
resultsUsing Affymetrix U133A array and analysis based on P ranking (P < 0.01) 1470 genes were identified as differentially expressed in leiomyomas compared to myometrium regardless of ethnicity. Of these, 268 genes were either over-expressed (177 genes) or under-expressed (91 genes) based on P < 0.01 followed by 2-fold cutoff selection in leiomyomas of A. Americans as compared to Caucasians. Among them, the expression E2F1, RUNX3, EGR3, TBPIP, ECM2, ESM1, THBS1, GAS1, ADAM17, CST6, CST7, FBLN5, ICAM2, EDN1 and COL18 was validated using realtime PCR low-density arrays. 2D PAGE coupled with image analysis identified 332 protein spots of which the density/volume of 31 varied by greater than or equal to 1.5 fold in leiomyomas as compared to myometrium. The density/volume of 34 protein-spots varied by greater than or equal to 1.5 fold (26 increased and 8 decreased) in leiomyomas of A. Americans as compared to Caucasians. Tandem mass spectrometric analysis of 15 protein spots identified several proteins whose transcripts were also identified by microarray, including 14-3-3 beta and mimecan, whose expression was confirmed using western blotting and immunohistochemistry.
conclusionThese findings imply that the level rather than the ethnic-specific expression of a number of genes and proteins may account for the difference between leiomyomas and possibly myometrium, in A. Americans and Caucasians. Further study using larger sample size is required to confirm these findings.
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Registered trials
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