ReviewAnnual review of clinical psychology2006
The psychopathology and treatment of bipolar disorder.
Review in Annual review of clinical psychology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization.BMC medicine · 2023Pooled it
- Emotional dysregulation as trans-nosographic psychopathological dimension in adulthood: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Serum folate levels in bipolar disorder: a systematic review and meta-analysis.BMC psychiatry · 2019Pooled it
- Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis.BMC medicine · 2014Pooled it
- Extreme attributions predict the course of bipolar depression: results from the STEP-BD randomized controlled trial of psychosocial treatment.The Journal of clinical psychiatry · 2013Trial
- Polygenicity shapes distinct brain patterns and clinical profiles of bipolar disorder.BMC medicine · 2026Article
- The Relationship Between Early-Stage Maladaptive Schemas and Treatment Adherence in Patients Diagnosed with Bipolar Disorder in Remission.Journal of clinical medicine · 2026Article
- Reward Processing in Mood Disorders and Schizophrenia: A Neurodevelopmental Framework.Annual review of clinical psychology · 2025Review
- Article
- Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats.Psychopharmacology · 2024Article
- The role of bipolar disorder and family wealth in choosing creative occupations.Scientific reports · 2024Article
- Manic Episodes in a Patient With Neurosyphilis Following Brief Discontinuation of Bipolar Medication.Cureus · 2023Article
- Microbiota-gut-brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities.Molecular psychiatry · 2023Review
- Is SARS-CoV-2 a Risk Factor of Bipolar Disorder?-A Narrative Review.Journal of clinical medicine · 2022Review
- Valproate Reverses Mania-Like Behavior ofNeuropsychiatric disease and treatment · 2021Article
- Differential Medication Attitudes to Antihypertensive and Mood Stabilizing Agents in response to an Automated Text-Messaging Adherence Enhancement Intervention.Journal of behavioral and cognitive therapy · 2020Article
- Positive and Negative Activation in the Mood Disorder Questionnaire: Associations With Psychopathology and Emotion Dysregulation in a Clinical Sample.Assessment · 2020Article
- Bipolar limbic expression of auto-immune thyroid targets: thyroglobulin and thyroid-stimulating hormone receptor.Metabolic brain disease · 2019Article
- Impulsivity and Behavior-Dependent Life Events Mediate the Relationship of Reward Sensitivity and Depression, but Not Hypomania, Among at-Risk Adolescents.Behavior therapy · 2019Article
- Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania.Biological psychiatry · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In this chapter we review research on the diagnosis, course, etiology, and pharmacological and psychosocial treatment of bipolar disorder (BD). BD is a highly recurrent and severe illness, with high rates of suicidality and functional impairment. The disorder is heritable and appears to share susceptibility genes with schizophrenia. It is characterized by dysregulation in the dopamine and serotonin systems and by pathology in the brain systems involved in regulating emotion. Psychosocial stressors, notably life events and familial expressed emotion, significantly influence the course of the illness in the context of these vulnerabilities. Findings of randomized clinical trials indicate that psychosocial interventions enhance long-term outcomes when added to pharmacotherapy. Much remains to be clarified about the interactive contributions of genetic, neurobiological, and psychosocial factors to the course of the disorder, and the moderators and mediators of treatment effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.