ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Functional organization of presynaptic metabotropic glutamate receptors in vagal brainstem circuits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Factors that affect heart rate variability following acute resistance exercise: A systematic review and meta-analysis.Journal of sport and health science · 2022Pooled it
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- Article
- DMV extrasynaptic NMDA receptors regulate caloric intake in rats.JCI insight · 2021Article
- Glutamatergic plasticity within neurocircuits of the dorsal vagal complex and the regulation of gastric functions.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Musings on the wanderer: What's new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Pancreas-Brain Crosstalk.Frontiers in neuroanatomy · 2021Article
- Astrocytic glutamate transporters reduce the neuronal and physiological influence of metabotropic glutamate receptors in nucleus tractus solitarii.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.Journal of neuroinflammation · 2019Review
- Central control of gastrointestinal motility.Current opinion in endocrinology, diabetes, and obesity · 2019Review
- Vagally mediated gastric effects of brain stem αAmerican journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Developmental regulation of inhibitory synaptic currents in the dorsal motor nucleus of the vagus in the rat.Journal of neurophysiology · 2016Article
- Vagal neurocircuitry and its influence on gastric motility.Nature reviews. Gastroenterology & hepatology · 2016Review
- Inhibitory neurotransmission regulates vagal efferent activity and gastric motility.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Presynaptic ionotropic glutamate receptors modulate GABA release in the mouse dorsal motor nucleus of the vagus.Neuroscience · 2015Article
- Characterization of synapses in the rat subnucleus centralis of the nucleus tractus solitarius.Journal of neurophysiology · 2015Article
- Article
- Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS.BioMed research international · 2015Article
- Exposure to a high fat diet during the perinatal period alters vagal motoneurone excitability, even in the absence of obesity.The Journal of physiology · 2015Article
- Plasticity in the brainstem vagal circuits controlling gastric motor function triggered by corticotropin releasing factor.The Journal of physiology · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We demonstrated previously that, by suppressing cAMP levels, metabotropic glutamate receptors (mGluRs) play a crucial role in opioid receptor trafficking on GABAergic nerve terminals within gastric brainstem vagal circuits. Using whole-cell patch-clamp recordings, we aimed to correlate the influence of sensory vagal afferent fibers with the functional organization of mGluRs on the synaptic connections between the nucleus tractus solitarius and dorsal motor nucleus of the vagus. Group II mGluRs were identified on both excitatory and inhibitory synapses; the receptor-selective agonist APDC [(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate] induced a concentration-dependent decrease in glutamatergic and GABAergic synaptic transmission (EC50, approximately 20 microM for both). The group II mGluRs were activated tonically on GABAergic, but not glutamatergic synapses, as the receptor-selective antagonist (2S)-alpha-ethylglutamic acid (EGLU; 200 microM) modulated GABA currents only. After selective vagal deafferentation, EGLU was without effect, suggesting that vagal afferent (sensory) fibers are the source of this tonic input. Conversely, group III mGluRs, although not activated tonically, were present on excitatory, but not inhibitory, synapses; in fact, the receptor-selective agonist L-AP-4 [L-(+)-2-amino-4-phosphonbutyric acid] induced a concentration-dependent decrease in glutamatergic synaptic transmission (EC50, approximately 2 microM) but had no effect on GABAergic synaptic transmission. Together with our previous results on receptor trafficking, these data suggest that visceral information plays a fundamental role in shaping the response of homeostatic brainstem circuits that receive inputs from higher integrative neuronal centers.
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