Evidence map›Paper›PMID 17715333›Full record

ArticleClinical and vaccine immunology : CVI2007

European multicenter evaluation of commercial enzyme immunoassays for detecting norovirus antigen in fecal samples.

Jim J Gray, Evelyne Kohli, Franco M Ruggeri, Harry Vennema, Alicia Sánchez-Fauquier, Eckart Schreier, Chris I Gallimore, Miren Iturriza-Gomara, Helene Giraudon, Pierre Pothier and 9 more

Open access · diamondAbstract readComparative StudyEvaluation StudyMulticenter Study
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 104 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Norovirus.Clinical microbiology reviews · 2015
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Evaluation of third-generation ELISA and a rapid immunochromatographic assay for the detection of norovirus infection in fecal samples from inpatients of a German tertiary care hospital.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012
    Article
  16. Norovirus infections in children under 5 years of age hospitalized due to the acute viral gastroenteritis in northeastern Poland.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 4 countries.

Jim J GrayEnteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, 61 Colindale Ave., London NW9 5HT, United Kingdom. jim.gray@hpa.org.uk
Evelyne Kohli
Franco M Ruggeri
Harry Vennema
Alicia Sánchez-Fauquier
Eckart Schreier
Chris I Gallimore
Miren Iturriza-Gomara
Helene Giraudon
Pierre Pothier
Ilaria Di Bartolo
Nadia Inglese
Erwin de Bruin
Bas van der Veer
Silvia Moreno
Vanessa Montero
Marí C de Llano
Marina Höhne
Sabine M Diedrich
Instituto de Salud Carlos III · ESIstituto Superiore di Sanità · ITNational Institute for Public Health and the Environment · NLRobert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A total of 2,254 fecal samples were tested in a European multicenter evaluation of commercially available norovirus antigen detection assays. Two commercial enzyme immunoassays, IDEIA Norovirus (Oxoid; Thermo Fisher Scientific, Ely, United Kingdom) and RIDASCREEN Norovirus (R-Biopharm, Darmstadt, Germany), were included in the evaluation, and their performance was compared with the results of reverse transcription-PCR (RT-PCR). Included in the evaluation were samples collected in sporadic cases of gastroenteritis, samples from outbreaks in which two or more samples were collected, well-characterized samples representing genotypes currently cocirculating within Europe, and samples collected from patients with gastroenteritis caused by a pathogen other than norovirus. The sensitivities and specificities of the IDEIA Norovirus and RIDASCREEN Norovirus assays were 58.93 and 43.81% and 93.91 and 96.37%, respectively, compared with RT-PCR. The sensitivities of both assays for outbreak investigations improved when six or more samples from an outbreak were examined. The IDEIA Norovirus assay exhibited reactivity to a broader range of norovirus genotypes than the RIDASCREEN Norovirus assay, which showed genotype-dependent sensitivities. The results indicate that, if used, these assays should serve as screening assays and the results should be confirmed by RT-PCR.

Indexed as

Immunoenzyme TechniquesAntigens, ViralCaliciviridae InfectionsEuropeFecesGastroenteritisHumansNorovirusReagent Kits, DiagnosticSensitivity and SpecificityAntigens, ViralReagent Kits, Diagnostic

Identifiers

PMID17715333
PMCPMC2168115
OpenAlexW2147609825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.