ArticleJournal of virology2007
Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporter.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- XPO1 coordinates human cytomegalovirus maturation by modulating genome encapsidation and secondary envelopment.Cell insight · 2026Article
- Article
- When cyclin-dependent kinases meet viral infections, including SARS-CoV-2.Journal of medical virology · 2022Review
- Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97.Viruses · 2021Article
- The Second-Generation XPO1 Inhibitor Eltanexor Inhibits Human Cytomegalovirus (HCMV) Replication and Promotes Type I Interferon Response.Frontiers in microbiology · 2021Article
- Review
- Article
- RO0504985 is an inhibitor of CMGC kinase proteins and has anti-human cytomegalovirus activity.Antiviral research · 2017Article
- CRM1 Inhibitors for Antiviral Therapy.Frontiers in microbiology · 2017Review
- Article
- Antiviral Efficacy of Verdinexor In Vivo in Two Animal Models of Influenza A Virus Infection.PloS one · 2016Article
- Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo.Journal of virology · 2014Article
- Review
- Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65.Medical microbiology and immunology · 2012Article
- Human cytomegalovirus UL97 kinase alters the accumulation of CDK1.The Journal of general virology · 2012Article
- Human cytomegalovirus tegument proteins (pp65, pp71, pp150, pp28).Virology journal · 2012Review
- Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44.Virology · 2011Article
- Cyclin-dependent kinase activity controls the onset of the HCMV lytic cycle.PLoS pathogens · 2010Article
- Human cytomegaloviruses expressing yellow fluorescent fusion proteins--characterization and use in antiviral screening.PloS one · 2010Article
- Biologic and immunologic effects of knockout of human cytomegalovirus pp65 nuclear localization signal.Clinical and vaccine immunology : CVI · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We have previously shown that treatment of human cytomegalovirus-infected cells with the cyclin-dependent kinase (cdk) inhibitor roscovitine has significant effects on several stages of the virus life cycle depending on the time of addition (V. Sanchez, A. K. McElroy, J. Yen, S. Tamrakar, C. L. Clark, R. A. Schwartz, and D. H. Spector, J. Virol. 78:11219-11232, 2004; V. Sanchez and D. Spector, J. Virol. 80:5886-5896, 2006). In this report, we add to these findings by demonstrating alterations in the phosphorylation and localization of pp65 (UL83) in cells treated with roscovitine. We observed that inhibition of cdk activity causes the retention of pp65 within the nucleus at late times postinfection. At the same time, we observed a change in the phosphorylation pattern of the protein. Interestingly, mutation of potential cdk phosphorylation sites did not affect the ability of pp65 to localize to the nucleus or to relocalize to the cytoplasm late in infection. However, we found that the cytoplasmic accumulation of pp65 late in infection was sensitive to the Crm1 inhibitor leptomycin B.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.