ArticleMolecular and cellular biochemistry2007
Alternol inhibits proliferation and induces apoptosis in mouse lymphocyte leukemia (L1210) cells.
Article in Molecular and cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Alternol inhibits GAPDH activity and disrupts glycolytic flux preferentially in cancer cells.Frontiers in pharmacology · 2026Article
- Overview of Bioactive Fungal Secondary Metabolites: Cytotoxic and Antimicrobial Compounds.Antibiotics (Basel, Switzerland) · 2022Review
- Alternol Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis.Frontiers in pharmacology · 2021Article
- Alternol triggers immunogenic cell deathOncoimmunology · 2021Article
- Natural compound Alternol as a novel therapeutic for prostate cancer treatment.American journal of clinical and experimental urology · 2020Review
- Alternol/Alteronol: Potent Anti-cancer Compounds With Multiple Mechanistic Actions.Frontiers in oncology · 2020Review
- Alteronol Enhances the Anti-tumor Activity and Reduces the Toxicity of High-Dose Adriamycin in Breast Cancer.Frontiers in pharmacology · 2019Article
- Alternol, a natural compound, exerts an anti-tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways.Journal of cellular and molecular medicine · 2017Article
- Growth inhibition and apoptosis induction by alternol in pancreatic carcinoma cells.World journal of gastroenterology · 2015Article
- Natural compound Alternol induces oxidative stress-dependent apoptotic cell death preferentially in prostate cancer cells.Molecular cancer therapeutics · 2014Article
- Alternol inhibits migration and invasion of human hepatocellular carcinoma cells by targeting epithelial-to-mesenchymal transition.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
Corrections and comments
- Retraction · 2023-11-23Concerns/Issues about Image · Unreliable Data · · see also: https://pubpeer.com/publications/64CA279556BE75033D8E9A9FE3C64D
- Retracted
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternol is a novel compound purified from the fermenting products by microorganisms named as Alternaria alternata var. monosporus from the bark of Yew. In this study, we tested its effect on mouse lymphocyte leukemia L1210 cells. Alternol was found to inhibit the proliferation and induce apoptosis in L1210 cells. When the cells were treated with Alternol, chromatin condensation and phosphatidylserine externalization were observed with the down-regulation of the pro-survival gene Bcl-2 and the activation of caspase-3, caspase-9, but not caspase-8. Moreover, exposure of cells to Alternol resulted in a significant increase in reactive oxygen species (ROS) and mitochondrial transmembrane potential (DeltaPsim) depolarization. Taken together, these results demonstrate that Alternol is a potent agent in inducing L1210 cells to apoptosis, which involve caspase activation and ROS generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.