Trial reportLipids2007
Bioequivalence of Docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food.
Trial report in Lipids, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01061554 (Correlation Between Level of Polyunsaturated Fatty Acid EPA and DHA in Blood After Digestion of ProBios Omega-3 Concordix™ Compared With Omega-3 Soft Capsules - a Pilot), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation Between Level of Polyunsaturated Fatty Acid EPA and DHA in Blood After Digestion of ProBios Omega-3 Concordix™ Compared With Omega-3 Soft Capsules - a Pilot
Who cites it
30 citing papers in PubMed, 134 citations in OpenAlex.
- Changes in fatty acid levels after consumption of a novel docosahexaenoic supplement from algae: a crossover randomized controlled trial in omnivorous, lacto-ovo vegetarians and vegans.European journal of nutrition · 2023Trial
- The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease.Alzheimer's research & therapy · 2016Trial
- A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study.Prostaglandins, leukotrienes, and essential fatty acids · 2011Trial
- Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial.JAMA · 2010Trial
- Short-term bioavailability of EPA and DHA from an algae oil-fortified soymilk compared with algae oil capsules.Food & function · 2026Article
- Ultrasonic-assistedFood chemistry: X · 2025Article
- Comparative Bioavailability of DHA and EPA from Microalgal and Fish Oil in Adults.International journal of molecular sciences · 2025Article
- Metabolic Engineering ofACS engineering Au · 2025Article
- Effects of algal oil as an alternative to fish oil in feline foods on serum concentrations of eicosapentaenoic acid and docosahexaenoic acid.Journal of animal science · 2025Article
- Biotechnological production of omega-3 fatty acids: current status and future perspectives.Frontiers in microbiology · 2023Review
- Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA.Foods (Basel, Switzerland) · 2022Review
- Production, Processing, and Protection of Microalgal n-3 PUFA-Rich Oil.Foods (Basel, Switzerland) · 2022Review
- Valorisation of algal biomass to value-added metabolites: emerging trends and opportunities.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022Review
- The Safe and Effective Use of Plant-Based Diets with Guidelines for Health Professionals.Nutrients · 2021Review
- Safety and Efficacy of Sodium and Potassium Arachidonic Acid Salts in the Young Pig.Nutrients · 2021Article
- Dementia risk reduction: why haven't the pharmacological risk reduction trials worked? An in-depth exploration of seven established risk factors.Alzheimer's & dementia (New York, N. Y.) · 2021Review
- Resveratrol Modulates Desaturase Expression and Fatty Acid Composition of Cultured Hepatocytes.Frontiers in nutrition · 2018Article
- Algae as nutritional and functional food sources: revisiting our understanding.Journal of applied phycology · 2017Review
- Docosahexaenoic Acid and Cognition throughout the Lifespan.Nutrients · 2016Review
- Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Docosahexaenoic acid (DHA), a long-chain omega-3 fatty acid, is important for eye and brain development and ongoing visual, cognitive, and cardiovascular health. Unlike fish-sourced oils, the bioavailability of DHA from vegetarian-sourced (algal) oils has not been formally assessed. We assessed bioequivalence of DHA oils in capsules from two different algal strains versus bioavailability from an algal-DHA-fortified food. Our 28-day randomized, placebo-controlled, parallel group study compared bioavailability of (a) two different algal DHA oils in capsules ("DHASCO-T" and "DHASCO-S") at doses of 200, 600, and 1,000 mg DHA per day (n = 12 per group) and of (b) an algal-DHA-fortified food (n = 12). Bioequivalence was based on changes in plasma phospholipid and erythrocyte DHA levels. Effects on arachidonic acid (ARA), docosapentaenoic acid-n-6 (DPAn-6), and eicosapentaenoic acid (EPA) were also determined. Both DHASCO-T and DHASCO-S capsules produced equivalent DHA levels in plasma phospholipids and erythrocytes. DHA response was dose-dependent and linear over the dose range, plasma phospholipid DHA increased by 1.17, 2.28 and 3.03 g per 100 g fatty acid at 200, 600, and 1,000 mg dose, respectively. Snack bars fortified with DHASCO-S oil also delivered equivalent amounts of DHA on a DHA dose basis. Adverse event monitoring revealed an excellent safety and tolerability profile. Two different algal oil capsule supplements and an algal oil-fortified food represent bioequivalent and safe sources of DHA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.