Evidence map›Paper›PMID 17713026›Full record

ReviewAdvances in experimental medicine and biology2007

Vaccine containing natural TLR ligands protects from Salmonella typhimurium infection in mice and acute respiratory infections in children.

Boris Semenov, Vitaly Zverev

Abstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. B cell TLRs and induction of immunoglobulin class-switch DNA recombination.Frontiers in bioscience (Landmark edition) · 2012
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Boris SemenovMechnikov Research Institute of Vaccines and Sera, Moscow, Russia. mech.inst@mail.ru
Vitaly Zverev

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been shown that a single parenteral administration of vaccine containing bacterial ligands for TLRI, TLR2, TLR4, TLR6, and TLR9 in mice induced rapid (24 h after administration) and effective (100%), but short-term (96 h) protection against lethal challenge with Salmonella typhimurium. Repeated mucosal applications of this vaccine stimulated long-term (up to 9 months) protection against acute respiratory infections in children of preschool age.

Indexed as

Acute DiseaseAnimalsChildHumansImmune SystemImmunity, InnateLigandsMiceMice, Inbred CBAMucous MembraneRespiratory Tract InfectionsSalmonella InfectionsSalmonella typhimuriumToll-Like ReceptorsLigandsToll-Like Receptors

Identifiers

PMID17713026
PMCPMC7123936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.