ArticlePlant molecular biology2007
Characterization of Arabidopsis thaliana genes encoding functional homologues of the yeast metal chaperone Cox19p, involved in cytochrome c oxidase biogenesis.
Article in Plant molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- The biogenesis and regulation of the plant oxidative phosphorylation system.Plant physiology · 2023Review
- Molecular Responses of Red Ripe Tomato Fruit to Copper Deficiency Stress.Plants (Basel, Switzerland) · 2023Article
- Tetratricopeptide-containing SMALL KERNEL 11 is essential for the assembly of cytochrome c oxidase in maize mitochondria.Plant physiology · 2023Article
- The mitochondrial copper chaperone COX19 influences copper and iron homeostasis in arabidopsis.Plant molecular biology · 2019Article
- The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants.International journal of molecular sciences · 2018Review
- Article
- Temporal aspects of copper homeostasis and its crosstalk with hormones.Frontiers in plant science · 2015Review
- Coordination of plant mitochondrial biogenesis: keeping pace with cellular requirements.Frontiers in plant science · 2014Review
- Cytoplasmic genome substitution in wheat affects the nuclear-cytoplasmic cross-talk leading to transcript and metabolite alterations.BMC genomics · 2013Article
- YSL16 is a phloem-localized transporter of the copper-nicotianamine complex that is responsible for copper distribution in rice.The Plant cell · 2012Article
- Facing the challenges of Cu, Fe and Zn homeostasis in plants.Nature chemical biology · 2009Review
- Characterization of promoter elements required for expression and induction by sucrose of the Arabidopsis COX5b-1 nuclear gene, encoding the zinc-binding subunit of cytochrome c oxidase.Plant molecular biology · 2009Article
- Mitochondrial biogenesis and function in Arabidopsis.The arabidopsis book · 2008Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis thaliana genome contains two nearly identical genes which encode proteins showing similarity with the yeast metal chaperone Cox19p, involved in cytochrome c oxidase biogenesis. One of these genes (AtCOX19-1) produces two transcript forms that arise from an alternative splicing event and encode proteins with different N-terminal portions. Both AtCOX19 isoforms are imported into mitochondria in vitro and are found attached to the inner membrane facing the intermembrane space. The smaller AtCOX19-1 isoform, but not the larger one, is able to restore growth on non-fermentable carbon sources when expressed in a yeast cox19 null mutant. AtCOX19 transcript levels increase by treatment with copper or compounds that produce reactive oxygen species. Young roots and anthers are highly stained in AtCOX19-1::GUS plants. Expression in leaves is only observed when cuts are produced, suggesting an induction by wounding. Infection of plants with the pathogenic bacterium Pseudomonas syringae pv. tomato also induces AtCOX19 gene expression. The results suggest that AtCOX19 genes encode functional homologues of the yeast metal chaperone. Induction by biotic and abiotic stress factors may indicate a relevant role of this protein in the biogenesis of cytochrome c oxidase to replace damaged forms of the enzyme or a more general role in the response of plants to stress.
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