ArticleBlood2007
Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- Silica Exposure Differentially Modulates Autoimmunity in Lupus Strains and Autoantibody Transgenic Mice.Frontiers in immunology · 2019Article
- Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1β and MCP-1 in cultured human retinal pigment epithelial cells.Experimental eye research · 2018Article
- Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice.European journal of immunology · 2018Article
- B Cell-ExtrinsicJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Colonic Insult Impairs Lymph Flow, Increases Cellular Content of the Lymph, Alters Local Lymphatic Microenvironment, and Leads to Sustained Inflammation in the Rat Ileum.Inflammatory bowel diseases · 2015Article
- Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models.Arthritis research & therapy · 2011Review
- Dendritic cells in systemic lupus erythematosus.International reviews of immunology · 2010Review
- Innate pathways to B-cell activation and tolerance.Annals of the New York Academy of Sciences · 2010Review
- Article
- B cells and immunological tolerance.The Journal of investigative dermatology · 2009Review
- Maintenance of tolerance by regulation of anti-myeloperoxidase B cells.Journal of the American Society of Nephrology : JASN · 2008Article
- Anti-Sm B cell tolerance and tolerance loss in systemic lupus erythematosus.Immunologic research · 2008Article
- The regulation of autoreactive B cells during innate immune responses.Immunologic research · 2008Article
- B-cell anergy: from transgenic models to naturally occurring anergic B cells?Nature reviews. Immunology · 2007Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Activation of the innate immune system promotes polyclonal antibody secretion to eliminate invading pathogens. Inherent in this process is the potential to activate autoreactive B cells and induce autoimmunity. We showed previously that TLR-stimulated dendritic cells and macrophages regulate B cell tolerance to Smith antigen, in part through the secretion of interleukin-6 (IL-6). In this manuscript, we show that neutralization of IL-6 fails to abrogate macrophage-mediated repression and identify soluble CD40 ligand (CD40L) as a second repressive factor secreted by macrophages. CD40L selectively repressed Ig secretion by chronically antigen-experienced (anergic) immunoglobulin transgenic and nontransgenic B cells but not by transiently stimulated B cells. The importance of macrophages in maintaining B cell tolerance was apparent in lupus-prone MRL/lpr mice. Compared with C57BL/6 mice, macrophages from MRL/lpr mice were significantly less efficient at repressing immunoglobulin secretion coincident with diminished IL-6 and CD40 ligand production. These data indicate that macrophages regulate autoreactive B cells by secreting repressive factors that prohibit terminal differentiation of B cells. The regulation of autoreactive B cells by macrophages is diminished in lupus-prone mice suggesting a role in autoimmunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.