ReviewSchizophrenia bulletin2007
Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia.
Review in Schizophrenia bulletin, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 158 citations in OpenAlex.
- Meta-analysis of paternal age and schizophrenia risk in male versus female offspring.Schizophrenia bulletin · 2011Pooled it
- Paternal age, de novo mutation, and age at onset among co-affected schizophrenia sib-pairs: whole-genome sequencing in multiplex families.Molecular psychiatry · 2025Article
- Associations of paternal age with offspring under-five mortality and perinatal outcomes: a cohort study using claims data in Taiwan.BMJ public health · 2024Article
- Paternal aging impacts expression and epigenetic markers as early as the first embryonic tissue lineage differentiation.Human genomics · 2024Article
- Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring.Genes · 2023Review
- Paternal age and 13 psychiatric disorders in the offspring: a population-based cohort study of 7 million children in Taiwan.Molecular psychiatry · 2022Article
- Paternal age and specific neurological soft signs as reliable and valid neurobiological markers for the diagnosis of patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2022Article
- Advanced paternal age and risk of schizophrenia in offspring - Review of epidemiological findings and potential mechanisms.Schizophrenia research · 2021Review
- Association between paternal age and risk of schizophrenia: a nationwide population-based study.Journal of assisted reproduction and genetics · 2021Article
- Aging Induces Profound Changes in sncRNA in Rat Sperm and These Changes Are Modified by Perinatal Exposure to Environmental Flame Retardant.International journal of molecular sciences · 2020Article
- Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study.Molecular autism · 2020Article
- The impact of parental psychopathology and sociodemographic factors in selective mutism - a nationwide population-based study.BMC psychiatry · 2020Article
- No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia.Schizophrenia bulletin · 2020Article
- Parental Risk Factors among Children with Reactive Attachment Disorder Referred to Specialized Services: A Nationwide Population-Based Study.Child psychiatry and human development · 2019Article
- JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk.Journal of neuroinflammation · 2019Article
- Older fathers' children have lower evolutionary fitness across four centuries and in four populations.Proceedings. Biological sciences · 2017Article
- Paternal age and psychiatric disorders: A review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms.Translational psychiatry · 2017Review
- Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models.Neural plasticity · 2016Review
- Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression.Molecular psychiatry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The causal mechanism underlying the well-established relation between advancing paternal age and schizophrenia is hypothesized to involve mutational errors during spermatogenesis that occur with increasing frequency as males age. Point mutations are well known to increase with advancing paternal age while other errors such as altered copy number in repeat DNA and chromosome breakage have in some cases also been associated with advancing paternal age. Dysregulation of epigenetic processes may also be an important mechanism underlying the association between paternal age and schizophrenia. Evidence suggests that advancing age as well as environmental exposures alter epigenetic regulation. Errors in epigenetic processes, such as parental imprinting can have serious effects on the offspring both pre- and postnatally and into adulthood. This article will discuss parental imprinting on the autosomal and X chromosomes and the alterations in epigenetic regulation that may lead to such errors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.