ArticleMicrocirculation (New York, N.Y. : 1994)2007
Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle.
Article in Microcirculation (New York, N.Y. : 1994), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Exercise intensity modulates capillary perfusion in correspondence with ACE I/D modulated serum angiotensin II levels.Applied & translational genomics · 2015Article
- The angiotensin converting enzyme insertion/deletion polymorphism alters the response of muscle energy supply lines to exercise.European journal of applied physiology · 2013Article
- The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat.Physiological genomics · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to determine whether a high-salt diet modulates physiological angiogenesis in skeletal muscle by altering angiotensin II (ANGII) and vascular endothelial growth factor (VEGF) levels.
methodsSprague-Dawley rats were placed on a control diet (0.4% NaCl by weight) or high-salt diet (4.0% NaCl) prior to treatment with the vasodilator prazosin in the drinking water. In addition, a group of animals fed high salt were infused intravenously with ANGII at a low dose to prevent ANGII suppression by high salt, and a group of rats fed control diet were treated with the angiotensin II type I (AT(1)) receptor blocker losartan and prazosin.
resultsPrazosin induced significant angiogenesis in the tibialis anterior muscle after 1 week of treatment. High-salt-fed rats demonstrated a complete inhibition of this angiogenic response. Maintenance of ANGII levels restored prazosin-induced angiogenesis in animals fed a high-salt diet. In addition, losartan treatment blocked prazosin-induced angiogenesis in animals on a control diet. Western blot analysis indicated that prazosin-induced angiogenesis was independent of changes in muscle levels of VEGF.
conclusionsThis study demonstrates an inhibitory effect of high salt intake on prazosin-induced angiogenesis. Further, these results indicate that ANGII acting through the AT(1) receptor is a critical pathway in this model of angiogenesis.
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