ArticleInfectious diseases in obstetrics and gynecology2007
Rapid determination of macrolide and lincosamide resistance in group B streptococcus isolated from vaginal-rectal swabs.
Article in Infectious diseases in obstetrics and gynecology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Analysis of virulence factors and antibiotic resistance genes in group B streptococcus from clinical samples.BMC infectious diseases · 2021Article
- Antibiotic-Resistant Genes and Pathogens Shed by Wild Deer Correlate with Land Application of Residuals.EcoHealth · 2018Article
- Development of a melting-curve based multiplex real-time PCR assay for simultaneous detection of Streptococcus agalactiae and genes encoding resistance to macrolides and lincosamides.BMC pregnancy and childbirth · 2018Article
- High Prevalence of Macrolide-resistance and Molecular Characterization ofFrontiers in microbiology · 2017Article
- Development of a Novel Test for Simultaneous Bacterial Identification and Antibiotic Susceptibility.Infectious diseases in obstetrics and gynecology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOur objective was to assess the ability of real-time PCR to predict in vitro resistance in isolates of group B streptococcus (GBS).
methodsThe first real-time PCR assays for the genes known to confer resistance to erythromycin and clindamycin in GBS were developed. Three hundred and forty clinical GBS isolates were assessed with these assays and compared with conventional disk diffusion.
resultsThe presence of an erythromycin ribosome methylation gene (ermB or ermTR variant A) predicted in vitro constitutive or inducible resistance to clindamycin with a sensitivity of 93% (95% CI 86%-97%), specificity of 90% (95% CI 85%-93%), positive predictive value of 76% (95% CI 67%-84%), and negative predictive value of 97% (95% CI 94%-99%).
conclusionThis rapid and simple assay can predict in vitro susceptibility to clindamycin within two hours of isolation as opposed to 18-24 hours via disk diffusion. The assay might also be used to screen large numbers of batched isolates to establish the prevalence of resistance in a given area.
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