ArticleNeoplasia (New York, N.Y.)2007
CITED1 expression in Wilms' tumor and embryonic kidney.
Article in Neoplasia (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Genetic variation frequencies in Wilms' tumor: A meta-analysis and systematic review.Cancer science · 2016Pooled it
- Multi-omics analysis identifies stemness-driven molecular subtypes, prognostic signature, epigenetic target APCDD1, and drug candidate Leflunomide in Wilms tumor.Frontiers in oncology · 2026Article
- Identification and Characterization of the Wilms Tumor Cancer Stem Cell.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Exploiting embryonic niche conditions to grow Wilms tumor blastema in culture.Frontiers in oncology · 2023Article
- FXR1 expression domain in Wilms tumor.Journal of pediatric surgery · 2019Article
- CITED1 contributes to the progression of papillary thyroid carcinoma via the Wnt/β-catenin signaling pathway.OncoTargets and therapy · 2019Article
- Molecular and epidemiologic characterization of Wilms tumor from Baghdad, Iraq.World journal of pediatrics : WJP · 2018Article
- CITED1 promotes proliferation of papillary thyroid cancer cells via the regulation of p21 and p27.Cell & bioscience · 2018Article
- The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour.PloS one · 2017Article
- Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.Development (Cambridge, England) · 2016Article
- Dermatoglyphics in kidney diseases: a review.SpringerPlus · 2016Review
- Genetic and chromosomal alterations in Kenyan Wilms Tumor.Genes, chromosomes & cancer · 2015Article
- Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor.Pediatric blood & cancer · 2014Article
- CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus.Oncotarget · 2014Article
- Cited1 deficiency suppresses intestinal tumorigenesis.PLoS genetics · 2013Article
- CITED1 expression in liver development and hepatoblastoma.Neoplasia (New York, N.Y.) · 2012Article
- Molecular characterization of Wilms' tumor from a resource-constrained region of sub-Saharan Africa.International journal of cancer · 2012Article
- SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.Journal of pediatric surgery · 2012Article
- FGF/EGF signaling regulates the renewal of early nephron progenitors during embryonic development.Development (Cambridge, England) · 2011Article
- Race disparities in Wilms tumor incidence and biology.The Journal of surgical research · 2011Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Wilms' tumors, or nephroblastomas, are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed metanephric mesenchyme within embryonic kidneys. We have previously shown that the transcriptional regulator CITED1 (CBP/p300-interacting transactivators with glutamic acid [E]/aspartic acid [D]-rich C-terminal domain) is expressed exclusively in these nephrogenic progenitor cells and is downregulated as they differentiate to form nephronic epithelia. In the current study, we show that CITED1 expression persists in blastemal cell populations of both experimental rat nephroblastomas and human Wilms' tumors, and that primary human Wilms' tumors presenting with disseminated disease show the highest level of CITED1 expression. Unlike the predominantly cytoplasmic subcellular localization of CITED1 in the normal developing kidney, CITED1 is clearly detectable in the nuclear compartment of Wilms' tumor blastema. These findings indicate that CITED1 is a marker of primitive blastema in Wilms' tumors and suggest that persistent expression and/or altered subcellular localization of CITED1 in the condensed metanephric mesenchyme could play a role in Wilms' tumor initiation and pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.