ArticleNeoplasia (New York, N.Y.)2007
c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells.
Article in Neoplasia (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Article
- Three-Dimensional Nuclear Telomere Profiling as a Biomarker for Recurrence in Oligodendrogliomas: A Pilot Study.International journal of molecular sciences · 2020Article
- Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy.Oncology letters · 2016Article
- c-MYC-induced genomic instability.Cold Spring Harbor perspectives in medicine · 2014Review
- A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins.Nature communications · 2013Article
- 3D nuclear organization and genomic instability in cancer.BMC proceedings · 2013Article
- c-Myc suppression of DNA double-strand break repair.Neoplasia (New York, N.Y.) · 2012Article
- Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival.British journal of cancer · 2011Article
- Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Dynamic chromosomal rearrangements in Hodgkin's lymphoma are due to ongoing three-dimensional nuclear remodeling and breakage-bridge-fusion cycles.Haematologica · 2010Article
- Three-dimensional nuclear telomere architecture is associated with differential time to progression and overall survival in glioblastoma patients.Neoplasia (New York, N.Y.) · 2010Article
- Telomere-centromere-driven genomic instability contributes to karyotype evolution in a mouse model of melanoma.Neoplasia (New York, N.Y.) · 2010Article
- The War on Cancer rages on.Neoplasia (New York, N.Y.) · 2009Article
- Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.Cancer genetics and cytogenetics · 2009Article
- Neoplasia: the second decade.Neoplasia (New York, N.Y.) · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Robertsonian (Rb) translocation chromosomes occur in human and murine cancers and involve the aberrant joining of two acrocentric chromosomes in humans and two telocentric chromosomes in mice. Mechanisms leading to their generation remain elusive, but models for their formation have been proposed. They include breakage of centromeric sequences and their subsequent fusions, centric misdivision, misparing between highly repetitive sequences of p-tel or p-arm repeats, and recombinational joining of centromeres and/or centromeric fusions. Here, we have investigated the role of the oncoprotein c-Myc in the formation of Rb chromosomes in mouse cells harboring exclusively telocentric chromosomes. In mouse plasmacytoma cells with constitutive c-Myc deregulation and in immortalized mouse lymphocytes with conditional c-Myc expression, we show that positional remodeling of centromeres in interphase nuclei coincides with the formation of Rb chromosomes. Furthermore, we demonstrate that c-Myc deregulation in a myc box II-dependent manner is sufficient to induce Rb translocation chromosomes. Because telomeric signals are present at all joined centromeres of Rb chromosomes, we conclude that c-Myc mediates Rb chromosome formation in mouse cells by telomere fusions at centromeric termini of telocentric chromosomes. Our findings are relevant to the understanding of nuclear chromosome remodeling during the initiation of genomic instability and tumorigenesis.
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