ArticlePloS one2007
Biphasic Hoxd gene expression in shark paired fins reveals an ancient origin of the distal limb domain.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 121 citations in OpenAlex.
- Evolutionary pathway and genetic mechanisms of fin-to-limb transition in vertebrates.Frontiers in cell and developmental biology · 2026Review
- Effects of Ceratotrichia Diameter and Packing Density on Chimaera Pectoral Fin Kinematics.Integrative organismal biology (Oxford, England) · 2026Article
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- The subfunctionalization ofFrontiers in cell and developmental biology · 2025Article
- Anterior-posterior constraint on Hedgehog signaling by hhip in teleost fin elaboration.Development (Cambridge, England) · 2024Article
- Relaxed selection in evolution of genes regulating limb development gives clue to variation in forelimb morphology of cetaceans and other mammals.Proceedings. Biological sciences · 2024Article
- The Chromosome-Scale Genome ofBiology · 2024Article
- Article
- Developmental independence of median fins from the larval fin fold revises their evolutionary origin.Scientific reports · 2022Article
- Article
- (Non)Parallel developmental mechanisms in vertebrate appendage reduction and loss.Ecology and evolution · 2021Review
- Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity.Nature communications · 2021Article
- Hoxd13/Bmp2-mediated mechanism involved in zebrafish finfold design.Scientific reports · 2021Article
- Article
- Growth trajectories of prenatal embryos of the deep-sea shark Chlamydoselachus anguineus (Chondrichthyes).Journal of fish biology · 2020Article
- Developmental constraints on fin diversity.Development, growth & differentiation · 2020Review
- A dot-stripe Turing model of joint patterning in the tetrapod limb.Development (Cambridge, England) · 2020Article
- A Logical Model of Homology for Comparative Biology.Systematic biology · 2020Article
- Molecular ontogeny of the stomach in the catshark Scyliorhinus canicula.Scientific reports · 2019Article
- The skeletal ontogeny of Astatotilapia burtoni - a direct-developing model system for the evolution and development of the teleost body plan.BMC developmental biology · 2018Article
2 more citing papers are in PubMed but not listed here.
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3 authors at 2 institutions in 1 country.
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Abstract
The evolutionary transition of fins to limbs involved development of a new suite of distal skeletal structures, the digits. During tetrapod limb development, genes at the 5' end of the HoxD cluster are expressed in two spatiotemporally distinct phases. In the first phase, Hoxd9-13 are activated sequentially and form nested domains along the anteroposterior axis of the limb. This initial phase patterns the limb from its proximal limit to the middle of the forearm. Later in development, a second wave of transcription results in 5' HoxD gene expression along the distal end of the limb bud, which regulates formation of digits. Studies of zebrafish fins showed that the second phase of Hox expression does not occur, leading to the idea that the origin of digits was driven by addition of the distal Hox expression domain in the earliest tetrapods. Here we test this hypothesis by investigating Hoxd gene expression during paired fin development in the shark Scyliorhinus canicula, a member of the most basal lineage of jawed vertebrates. We report that at early stages, 5'Hoxd genes are expressed in anteroposteriorly nested patterns, consistent with the initial wave of Hoxd transcription in teleost and tetrapod paired appendages. Unexpectedly, a second phase of expression occurs at later stages of shark fin development, in which Hoxd12 and Hoxd13 are re-expressed along the distal margin of the fin buds. This second phase is similar to that observed in tetrapod limbs. The results indicate that a second, distal phase of Hoxd gene expression is not uniquely associated with tetrapod digit development, but is more likely a plesiomorphic condition present the common ancestor of chondrichthyans and osteichthyans. We propose that a temporal extension, rather than de novo activation, of Hoxd expression in the distal part of the fin may have led to the evolution of digits.
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