ArticleReproduction (Cambridge, England)2007
Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes.
Article in Reproduction (Cambridge, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Improved biomarker discovery through a plot twist in transcriptomic data analysis.BMC biology · 2022Article
- Retinoic Acid Induced Protein 14 (PeerJ · 2021Article
- Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat.Biology of sex differences · 2020Article
- Broad Phenotypes of Disorders/Differences of Sex Development inFrontiers in genetics · 2019Article
- Environmentally induced epigenetic transgenerational inheritance of male infertility.Current opinion in genetics & development · 2014Review
- Characterization of gonadal transcriptomes from Nile tilapia (Oreochromis niloticus) reveals differentially expressed genes.PloS one · 2013Article
- SRY induced TCF21 genome-wide targets and cascade of bHLH factors during Sertoli cell differentiation and male sex determination in rats.Biology of reproduction · 2012Article
- Environmentally induced epigenetic transgenerational inheritance of phenotype and disease.Molecular and cellular endocrinology · 2012Review
- Gametogenesis in the Pacific oyster Crassostrea gigas: a microarrays-based analysis identifies sex and stage specific genes.PloS one · 2012Article
- Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9.PloS one · 2012Article
- SRY directly regulates the neurotrophin 3 promoter during male sex determination and testis development in rats.Biology of reproduction · 2011Article
- Identification of candidate genes and physiological pathways involved in gonad deformation in whitefish (Coregonus spp.) from Lake Thun, Switzerland.International journal of environmental research and public health · 2011Article
- Uncovering gene regulatory networks during mouse fetal germ cell development.Biology of reproduction · 2011Article
- Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation.Reproductive biology and endocrinology : RB&E · 2011Article
- Basic helix-loop-helix transcription factor TCF21 is a downstream target of the male sex determining gene SRY.PloS one · 2011Article
- Alterations in the developing testis transcriptome following embryonic vinclozolin exposure.Reproductive toxicology (Elmsford, N.Y.) · 2010Article
- Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective.Frontiers in neuroendocrinology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Gene expression profiles during sex determination and gonadal differentiation were investigated to identify new potential regulatory factors. Embryonic day 13 (E13), E14, and E16 rat testes and ovaries were used for microarray analysis, as well as E13 testis organ cultures that undergo testis morphogenesis and develop seminiferous cords in vitro. A list of 109 genes resulted from a selective analysis for genes present in male gonadal development and with a 1.5-fold change in expression between E13 and E16. Characterization of these 109 genes potentially important for testis development revealed that cytoskeletal-associated proteins, extracellular matrix factors, and signaling factors were highly represented. Throughout the developmental period (E13-E16), sex-enriched transcripts were more prevalent in the male with 34 of the 109 genes having testis-enriched expression during sex determination. In ovaries, the total number of transcripts with a 1.5-fold change in expression between E13 and E16 was similar to the testis, but none of those genes were both ovary enriched and regulated during the developmental period. Genes conserved in sex determination were identified by comparing changing transcripts in the rat analysis herein, to transcripts altered in previously published mouse studies of gonadal sex determination. A comparison of changing mouse and rat transcripts identified 43 genes with species conservation in sex determination and testis development. Profiles of gene expression during E13-E16 rat testis and ovary development are presented and candidate genes for involvement in sex determination and testis differentiation are identified. Analysis of cellular pathways did not reveal any specific pathways involving multiple candidate genes. However, the genes and gene network identified influence numerous cellular processes with cellular differentiation, proliferation, focal contact, RNA localization, and development being predominant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.