ArticleJournal of immunology (Baltimore, Md. : 1950)2007
Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- γδ T Cells and Allergic Diseases.Clinical reviews in allergy & immunology · 2023Review
- Review
- γδ T Lymphocytes in Asthma: a Complicated Picture.Archivum immunologiae et therapiae experimentalis · 2021Review
- Spectrum of T-lymphocyte activities regulating allergic lung inflammation.Immunological reviews · 2017Review
- NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.PloS one · 2017Article
- Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells.Frontiers in cellular and infection microbiology · 2017Article
- Aligning mouse models of asthma to human endotypes of disease.Respirology (Carlton, Vic.) · 2014Review
- The role of the γ δ T cell in allergic diseases.Journal of immunology research · 2014Review
- γδT cells suppress inflammation and disease during rhinovirus-induced asthma exacerbations.Mucosal immunology · 2013Article
- Involvement of commensal bacteria may lead to dysregulated inflammatory and autoimmune responses in a mouse model for chronic nonsuppurative destructive cholangitis.Journal of clinical immunology · 2012Article
- Immunomodulation at epithelial sites by obesity and metabolic disease.Immunologic research · 2012Review
- A novel role for NKT cells in cutaneous wound repair.The Journal of surgical research · 2011Article
- γδ T cells are required for maximal expression of allergic conjunctivitis.Investigative ophthalmology & visual science · 2011Article
- Article
- Chronic inflammation and asthma.Mutation research · 2010Review
- gammadelta T cell subsets: a link between TCR and function?Seminars in immunology · 2010Review
- Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity.Nature reviews. Immunology · 2010Review
- Analysis of gamma delta T cell functions in the mouse.Journal of immunology (Baltimore, Md. : 1950) · 2010Review
- Toll-like receptor 3 ligand dampens liver inflammation by stimulating Valpha 14 invariant natural killer T cells to negatively regulate gammadeltaT cells.The American journal of pathology · 2010Article
- A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Mice sensitized and challenged with OVA were used to investigate the role of innate T cells in the development of allergic airway hyperresponsiveness (AHR). AHR, but not eosinophilic airway inflammation, was induced in T cell-deficient mice by small numbers of cotransferred gammadelta T cells and invariant NKT cells, whereas either cell type alone was not effective. Only Vgamma1+Vdelta5+ gammadelta T cells enhanced AHR. Surprisingly, OVA-specific alphabeta T cells were not required, revealing a pathway of AHR development mediated entirely by innate T cells. The data suggest that lymphocytic synergism, which is key to the Ag-specific adaptive immune response, is also intrinsic to T cell-dependent innate responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.