ArticleAntimicrobial agents and chemotherapy2007
Molecular and epidemiological evidence for spread of multiresistant methicillin-susceptible Staphylococcus aureus strains in hospitals.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Characterization of SCCAntimicrobial agents and chemotherapy · 2022Article
- Diversity of SCCmec elements and spa types in South African Staphylococcus aureus mecA-positive blood culture isolates.BMC infectious diseases · 2020Article
- Antimicrobial Resistance and Molecular Characteristics of Methicillin-resistantInfection and drug resistance · 2019Article
- Discriminatory Indices of Typing Methods for Epidemiologic Analysis of Contemporary Staphylococcus aureus Strains.Medicine · 2015Article
- Evaluation of BD Max StaphSR and BD Max MRSAXT Assays Using ESwab-Collected Specimens.Journal of clinical microbiology · 2015Article
- Contamination of environmental surfaces with Staphylococcus aureus in households with children infected with methicillin-resistant S aureus.JAMA pediatrics · 2014Article
- Laboratory evaluation of the BD MAX MRSA assay.Journal of clinical microbiology · 2014Article
- Detection of methicillin-resistant Staphylococcus aureus by a duplex droplet digital PCR assay.Journal of clinical microbiology · 2013Article
- Ward-specific rates of nasal cocolonization with methicillin-susceptible and -resistant Staphylococcus spp. and potential impact on molecular methicillin-resistant Staphylococcus aureus screening tests.Journal of clinical microbiology · 2013Article
- Isolation and characterization of Staphylococcus aureus strains from a Paso del Norte dairy.Journal of dairy science · 2013Article
- Multiplex real-time PCR assay for detection of methicillin-resistant Staphylococcus aureus (MRSA) strains suitable in regions of high MRSA endemicity.Journal of clinical microbiology · 2013Article
- Methicillin-resistant Staphylococcus aureus in nasal surveillance swabs at an intensive care unit: an evaluation of the LightCycler MRSA advanced test.Annals of laboratory medicine · 2012Article
- Population genetic structures of Staphylococcus aureus isolates from cats and dogs in Japan.Journal of clinical microbiology · 2012Article
- Detection and characterisation of SCCmec remnants in multiresistant methicillin-susceptible Staphylococcus aureus causing a clonal outbreak in a Swedish county.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Detection of methicillin-resistant Staphylococcus aureus (MRSA) from nasal samples by multiplex real-time PCR based on dual priming AT-rich primers.Folia microbiologica · 2012Article
- Molecular methods and platforms for infectious diseases testing a review of FDA-approved and cleared assays.The Journal of molecular diagnostics : JMD · 2011Review
- Prevalence and genetic relatedness of methicillin-susceptible Staphylococcus aureus isolates detected by the Xpert MRSA nasal assay.Journal of clinical microbiology · 2011Article
- Genotypic and phenotypic characterization of methicillin-susceptible Staphylococcus aureus isolates misidentified as methicillin-resistant Staphylococcus aureus by the BD GeneOhm MRSA assay.Journal of clinical microbiology · 2011Article
- Comparison of the BD GeneOhm methicillin-resistant Staphylococcus aureus (MRSA) PCR assay to culture by use of BBL CHROMagar MRSA for detection of MRSA in nasal surveillance cultures from intensive care unit patients.Journal of clinical microbiology · 2010Article
- Contribution of two molecular assays as compared to selective culture for MRSA screening in a low MRSA prevalence population.Infection · 2010Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The excision of the staphylococcal chromosomal cassette mec (SCCmec) from methicillin-resistant Staphylococcus aureus (MRSA) strains results in methicillin-susceptible S. aureus (MSSA) strains. In order to determine the proportion and diversity of multidrug-resistant MSSA (MR-MSSA) strains derived from MRSA strains, 247 mecA-negative isolates recovered in 60 French hospitals between 2002 and 2004 were characterized. The spa types of all strains were determined, and a subset of the strains (n = 30) was further genotyped by multilocus sequence typing. The IDI-MRSA assay was used to test the isolates for the presence of the SCCmec element, which was detected in 68% of all isolates analyzed. Molecular analysis of the samples suggested that 92% of the MR-MSSA isolates were derived from MRSA clones of diverse genetic backgrounds, of which the clone of sequence type 8 and SCCmec type IV(A) accounted for most of the samples. High variations in incidence data and differences in the molecular characteristics of the isolates from one hospital to another indicate that the emergence of MR-MSSA resulted from independent SCCmec excisions from epidemic MRSA isolates, as well as the diffusion of methicillin-susceptible strains after the loss of SCCmec. MR-MSSA could constitute a useful model for the study of the respective genetic and environmental factors involved in the dissemination of S. aureus in hospitals.
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