ArticleInfection and immunity2007
Contribution of the stg fimbrial operon of Salmonella enterica serovar Typhi during interaction with human cells.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Identification of OxyR as an activator of type 1 fimbriae (Microbiology spectrum · 2025Article
- Salmonella enterica virulence databases and bioinformatic analysis tools development.Scientific reports · 2024Article
- Complete genome sequence, phenotypic correlation and pangenome analysis of uropathogenic Klebsiella spp.AMB Express · 2024Article
- Differential regulatory control of curli (csg) gene expression in Salmonella enterica serovar Typhi requires more than a functional CsgD regulator.Scientific reports · 2023Article
- Antimicrobial resistance genes, virulence markers and prophage sequences inCurrent research in microbial sciences · 2022Article
- New Insights on the Early Interaction Between Typhoid and Non-typhoidFrontiers in microbiology · 2021Review
- New Roles for Two-Component System Response Regulators ofMicroorganisms · 2020Article
- Identification and characterisation of enteroaggregative Escherichia coli subtypes associated with human disease.Scientific reports · 2020Article
- Functional Analysis of the Chaperone-Usher Fimbrial Gene Clusters ofFrontiers in cellular and infection microbiology · 2018Article
- New Insights into the Roles of Long Polar Fimbriae and Stg Fimbriae in Salmonella Interactions with Enterocytes and M Cells.Infection and immunity · 2017Article
- Article
- Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to studyNPJ microgravity · 2017Article
- A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis.Frontiers in microbiology · 2017Article
- Mutational Studies of Putative Biosynthetic Genes for the Cyanobacterial Sunscreen Scytonemin in Nostoc punctiforme ATCC 29133.Frontiers in microbiology · 2016Article
- stg fimbrial operon from S. Typhi STH2370 contributes to association and cell disruption of epithelial and macrophage-like cells.Biological research · 2015Article
- Environmental regulation of the long polar fimbriae 2 of enterohemorrhagic Escherichia coli O157:H7.FEMS microbiology letters · 2014Article
- Ethanolamine and choline promote expression of putative and characterized fimbriae in enterohemorrhagic Escherichia coli O157:H7.Infection and immunity · 2014Article
- Salmonella as a vaccine delivery vehicle.Expert review of vaccines · 2013Review
- Chromosomal complementation using Tn7 transposon vectors in Enterobacteriaceae.Applied and environmental microbiology · 2012Article
- Characterization of a novel chaperone/usher fimbrial operon present on KpGI-5, a methionine tRNA gene-associated genomic island in Klebsiella pneumoniae.BMC microbiology · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella serovars contain a wide variety of putative fimbrial systems that may contribute to colonization of specific niches. Salmonella enterica serovar Typhi is the etiologic agent of typhoid fever and is a pathogen specific to humans. In a previous study, we identified a gene, STY3920 (stgC), encoding the predicted usher of the stg fimbrial operon, that was expressed by serovar Typhi during infection of human macrophages. The stg genes are located in the glmS-pstS intergenic region in serovar Typhi and certain Escherichia coli strains, but they are absent in other S. enterica serovars. We cloned the stg fimbrial operon into a nonfimbriate E. coli K-12 strain and into S. enterica serovar Typhimurium. We demonstrated that the stg fimbrial operon contributed to increased adherence to human epithelial cells. Transcriptional fusion assays with serovar Typhi suggested that stg is preferentially expressed in minimal medium. Deletion of stg reduced adherence of serovar Typhi to epithelial cells. However, deletion of stg increased uptake of serovar Typhi by human macrophages, and overexpression of stg in serovar Typhi and serovar Typhimurium strains reduced phagocytosis by human macrophages. These strains survived inside macrophages as well as the wild-type parent. Although the stgC gene contains a premature stop codon that disrupts the expected open reading frame encoding the usher and is therefore considered a pseudogene, our results show that the stg operon may encode a functional fimbria. Thus, this serovar Typhi-specific fimbrial operon contributes to interactions with host cells, and further characterization is important for understanding the role of the stg fimbrial cluster in typhoid fever pathogenesis.
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