ArticleInfection and immunity2007
L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
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- Vancomycin-resistant enterococci utilise antibiotic-enriched nutrients for intestinal colonisation.Nature communications · 2025Article
- Non-canonical start codons confer context-dependent advantages in carbohydrate utilization for commensal E. coli in the murine gut.Nature microbiology · 2024Article
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- Antibiotics promote intestinal growth of carbapenem-resistant Enterobacteriaceae by enriching nutrients and depleting microbial metabolites.Nature communications · 2023Article
- L-Fucose is involved in human-gut microbiome interactions.Applied microbiology and biotechnology · 2023Review
- Transcription Factor SrsR (YgfI) Is a Novel Regulator for the Stress-Response Genes in Stationary Phase inInternational journal of molecular sciences · 2022Article
- Functional Analysis of Deoxyhexose Sugar Utilization in Escherichia coli Reveals Fermentative Metabolism under Aerobic Conditions.Applied and environmental microbiology · 2021Article
- Mechanism of the Gut Microbiota Colonization Resistance and Enteric Pathogen Infection.Frontiers in cellular and infection microbiology · 2021Review
- Nitrate Is Crucial for the Proliferation of GutFrontiers in microbiology · 2020Article
- A SimpleApplied and environmental microbiology · 2018Article
- The Interactions between Host Glycobiology, Bacterial Microbiota, and Viruses in the Gut.Viruses · 2018Review
- Relevance of secretor status genotype and microbiota composition in susceptibility to rotavirus and norovirus infections in humans.Scientific reports · 2017Article
- Review
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- Frenemies: Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions.Cell host & microbe · 2015Review
- An L-Fucose Operon in the Probiotic Lactobacillus rhamnosus GG Is Involved in Adaptation to Gastrointestinal Conditions.Applied and environmental microbiology · 2015Article
- Enteric Pathogens Exploit the Microbiota-generated Nutritional Environment of the Gut.Microbiology spectrum · 2015Article
- Commensal and Pathogenic Escherichia coli Metabolism in the Gut.Microbiology spectrum · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Escherichia coli MG1655 uses several sugars for growth in the mouse intestine. To determine the roles of L-fucose and D-ribose, an E. coli MG1655 DeltafucAO mutant and an E. coli MG1655 DeltarbsK mutant were fed separately to mice along with wild-type E. coli MG1655. The E. coli MG1655 DeltafucAO mutant colonized the intestine at a level 2 orders of magnitude lower than that of the wild type, but the E. coli MG1655 DeltarbsK mutant and the wild type colonized at nearly identical levels. Surprisingly, an E. coli MG1655 DeltafucAO DeltarbsK mutant was eliminated from the intestine by either wild-type E. coli MG1655 or E. coli MG1655 DeltafucAO, suggesting that the DeltafucAO mutant switches to ribose in vivo. Indeed, in vitro growth experiments showed that L-fucose stimulated utilization of D-ribose by the E. coli MG1655 DeltafucAO mutant but not by an E. coli MG1655 DeltafucK mutant. Since the DeltafucK mutant cannot convert L-fuculose to L-fuculose-1-phosphate, whereas the DeltafucAO mutant accumulates L-fuculose-1-phosphate, the data suggest that L-fuculose-1-phosphate stimulates growth on ribose both in the intestine and in vitro. An E. coli Nissle 1917 DeltafucAO mutant, derived from a human probiotic commensal strain, acted in a manner identical to that of E. coli MG1655 DeltafucAO in vivo and in vitro. Furthermore, L-fucose at a concentration too low to support growth stimulated the utilization of ribose by the wild-type E. coli strains in vitro. Collectively, the data suggest that L-fuculose-1-phosphate plays a role in the regulation of ribose usage as a carbon source by E. coli MG1655 and E. coli Nissle 1917 in the mouse intestine.
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