ArticleMolecular and cellular biology2007
A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
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- Comprehensive Analysis of DNA 5-Methylcytosine and N6-Adenine Methylation by Nanopore Sequencing in Hepatocellular Carcinoma.Frontiers in cell and developmental biology · 2022Article
- Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma.Cancer research communications · 2021Article
- Review
- Global landscape and genetic regulation of RNA editing in cortical samples from individuals with schizophrenia.Nature neuroscience · 2019Article
- Article
- Identification of Shared Genes Between Ischemic Stroke and Parkinson's Disease Using Genome-Wide Association Studies.Frontiers in neurology · 2019Article
- Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases.Journal of immunology research · 2016Review
- Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease.Stem cells (Dayton, Ohio) · 2014Article
- ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Biochimica et biophysica acta · 2014Review
- The regulation and deregulation of Wnt signaling by PARK genes in health and disease.Journal of molecular cell biology · 2014Review
- Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair.The European journal of neuroscience · 2013Review
- Wnt your brain be inflamed? Yes, it Wnt!Trends in molecular medicine · 2013Review
- LRRK2: an éminence grise of Wnt-mediated neurogenesis?Frontiers in cellular neuroscience · 2013Article
- Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells.PloS one · 2013Article
- NR4A2 is regulated by gastrin and influences cellular responses of gastric adenocarcinoma cells.PloS one · 2013Article
- Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers.World journal of gastroenterology · 2012Article
- Association of Nurr1 gene mutations with Parkinson's disease in the Han population living in the Hubei province of China.Neural regeneration research · 2012Article
- Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77.Oncogene · 2012Article
- A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection.Molecular neurodegeneration · 2011Article
Corrections and comments
- Retraction · 2014-03-01Concerns/Issues about Data · Ethical Violations by Author · Investigation by Company/Institution · Manipulation of Images · Unreliable Data ·
- Expression of concern · 2013-06-01Concerns/Issues about Data · Investigation by Company/Institution · Unreliable Data ·
- Expression of concern
- Retracted
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The orphan nuclear receptor Nurr1 is essential for the development and maintenance of midbrain dopaminergic neurons, the cells that degenerate during Parkinson's disease, by promoting the transcription of genes involved in dopaminergic neurotransmission. Since Nurr1 lacks a classical ligand-binding pocket, it is not clear which factors regulate its activity and how these factors are affected during disease pathogenesis. Since Wnt signaling via beta-catenin promotes the differentiation of Nurr1(+) dopaminergic precursors in vitro, we tested for functional interactions between these systems. We found that beta-catenin and Nurr1 functionally interact at multiple levels. In the absence of beta-catenin, Nurr1 is associated with Lef-1 in corepressor complexes. Beta-catenin binds Nurr1 and disrupts these corepressor complexes, leading to coactivator recruitment and induction of Wnt- and Nurr1-responsive genes. We then identified KCNIP4/calsenilin-like protein as being responsive to concurrent activation by Nurr1 and beta-catenin. Since KCNIP4 interacts with presenilins, the Alzheimer's disease-associated proteins that promote beta-catenin degradation, we tested the possibility that KCNIP4 induction regulates beta-catenin signaling. KCNIP4 induction limited beta-catenin activity in a presenilin-dependent manner, thereby serving as a negative feedback loop; furthermore, Nurr1 inhibition of beta-catenin activity was absent in PS1(-/-) cells or in the presence of small interfering RNAs specific to KCNIP4. These data describe regulatory convergence between Nurr1 and beta-catenin, providing a mechanism by which Nurr1 could be regulated by Wnt signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.