ArticleMolecular and cellular biology2007
Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- The 3'-5' exoribonuclease ISG20L2 contributes to 3' terminus maturation of 18S and 28S ribosomal RNAs.Nucleic acids research · 2025Article
- Antisense pairing and SNORD13 structure guide RNA cytidine acetylation.RNA (New York, N.Y.) · 2022Article
- Human NOP2/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C/D snoRNPs.Nucleic acids research · 2022Article
- The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization.Biomolecules · 2022Review
- The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27.Nucleic acids research · 2020Article
- Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts.American journal of human genetics · 2020Article
- Long-range function of secreted small nucleolar RNAs that direct 2'-The Journal of biological chemistry · 2018Article
- Nuclear export factor 3 regulates localization of small nucleolar RNAs.The Journal of biological chemistry · 2017Article
- Assembly and trafficking of box C/D and H/ACA snoRNPs.RNA biology · 2017Review
- La Deletion from Mouse Brain Alters Pre-tRNA Metabolism and Accumulation of Pre-5.8S rRNA, with Neuron Death and Reactive Astrocytosis.Molecular and cellular biology · 2017Article
- The circadian dynamics of small nucleolar RNA in the mouse liver.Journal of the Royal Society, Interface · 2017Article
- Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.Nature genetics · 2016Article
- Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase.The Journal of biological chemistry · 2015Article
- Nutritional status modulates box C/D snoRNP biogenesis by regulated subcellular relocalization of the R2TP complex.Genome biology · 2014Article
- Structural and functional analysis of the U3 snoRNA binding protein Rrp9.RNA (New York, N.Y.) · 2013Article
- The profile of snoRNA-derived microRNAs that regulate expression of variant surface proteins in Giardia lamblia.Cellular microbiology · 2012Article
- Beyond tRNA cleavage: novel essential function for yeast tRNA splicing endonuclease unrelated to tRNA processing.Genes & development · 2012Article
- Gene regulation in Giardia lambia involves a putative microRNA derived from a small nucleolar RNA.PLoS neglected tropical diseases · 2011Article
- Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress.Cell metabolism · 2011Article
- CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport.The EMBO journal · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Box C/D snoRNPs, factors essential for ribosome biogenesis, are proposed to be assembled in the nucleoplasm before localizing to the nucleolus. However, recent work demonstrated the involvement of nuclear export factors in this process, suggesting that export may take place. Here we show that there are distinct distributions of U8 pre-snoRNAs and pre-snoRNP complexes in HeLa cell nuclear and cytoplasmic extracts. We observed differential association of nuclear export (PHAX, CRM1, and Ran) factors with complexes in the two extracts, consistent with nucleocytoplasmic transport. Furthermore, we show that the U8 pre-snoRNA in one of the cytoplasmic complexes contains an m3G cap and is associated with the nuclear import factor Snurportin1. Using RNA interference, we show that loss of either PHAX or Snurportin1 results in the incorrect localization of the U8 snoRNA. Our data therefore show that nuclear export and import factors are directly involved in U8 box C/D snoRNP biogenesis. The distinct distribution of U8 pre-snoRNP complexes between the two cellular compartments together with the association of both nuclear import and export factors with the precursor complex suggests that the mammalian U8 snoRNP is exported during biogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.