ArticleMolecular and cellular biology2007
A highly polymorphic meiotic recombination mouse hot spot exhibits incomplete repair.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- The impact of poly-A microsatellite heterologies in meiotic recombination.Life science alliance · 2019Article
- Connecting theory and data to understand recombination rate evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice.Cell cycle (Georgetown, Tex.) · 2017Article
- Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.Molecular and cellular biology · 2017Article
- Article
- Local and sex-specific biases in crossover vs. noncrossover outcomes at meiotic recombination hot spots in mice.Genes & development · 2015Article
- Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics.Nature genetics · 2014Article
- Contrasted patterns of crossover and non-crossover at Arabidopsis thaliana meiotic recombination hotspots.PLoS genetics · 2013Article
- Preaching about the converted: how meiotic gene conversion influences genomic diversity.Annals of the New York Academy of Sciences · 2012Review
- Isolation of meiotic recombinants from mouse sperm.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Initiation of meiotic recombination in mammals.Genes · 2010Article
- A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility.Genome research · 2010Article
- Comprehensive, fine-scale dissection of homologous recombination outcomes at a hot spot in mouse meiosis.Molecular cell · 2010Article
- Nucleosome occupancy landscape and dynamics at mouse recombination hotspots.EMBO reports · 2010Article
- Anatomy of mouse recombination hot spots.Nucleic acids research · 2010Article
- Mammalian recombination hot spots: properties, control and evolution.Nature reviews. Genetics · 2010Review
- Genetic crossovers are predicted accurately by the computed human recombination map.PLoS genetics · 2010Article
- The recombinational anatomy of a mouse chromosome.PLoS genetics · 2008Article
- Organization and roles of nucleosomes at mouse meiotic recombination hotspots.Nucleus (Austin, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent mapping of recombination hot spots in the human genome has demonstrated that crossover is a nonrandom process that occurs at well-defined positions along chromosomes. However, the mechanisms that direct hot-spot turnover in complex mammalian genomes are poorly understood. Analyses of the human genome are impaired by the inability to genetically dissect and molecularly manipulate recombinogenic regions to test their roles in regulating hot spots. Here, using the BXD recombinant inbred strains as a crossover library, three new recombination hot spots have been identified on mouse chromosome 19. Analyses of a highly polymorphic recombination hot spot (HS22) revealed that approximately 4% of recombinant molecules display complex and incomplete repair with discontinuous conversion tracts, as well as persistent heteroduplex DNA at crossover sites in mature spermatozoa. Also, sequence analysis of the wild house mouse revealed instability at the center of this hot spot. This suggests that complete repair is not required for completion of mammalian meiosis, a scenario that leaves duplex DNA containing mismatches at crossover sites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.