ArticleMechanisms of development
Functional distinctness of closely related transcription factors: a comparison of the Atonal and Amos proneural factors.
Article in Mechanisms of development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- ASCL1 protein domains with distinct functions in neuronal differentiation and subtype specification.Developmental biology · 2025Article
- Functional analysis of sense organ specification in the Tribolium castaneum larva reveals divergent mechanisms in insects.BMC biology · 2021Article
- Homeostatic maintenance and age-related functional decline in the Drosophila ear.Scientific reports · 2020Article
- All in the family: proneural bHLH genes and neuronal diversity.Development (Cambridge, England) · 2018Review
- The role of Atonal transcription factors in the development of mechanosensitive cells.Seminars in cell & developmental biology · 2013Review
- Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit.Molecular and cellular neurosciences · 2013Article
- Identification of Bombyx atonal and functional comparison with the Drosophila atonal proneural factor in the developing fly eye.Genesis (New York, N.Y. : 2000) · 2012Article
- Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystems.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesis.Cellular and molecular life sciences : CMLS · 2010Review
- The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis.BMC developmental biology · 2010Article
- Molecular cloning and characterization of homologs of achaete-scute and hairy-enhancer of split in the olfactory organ of the spiny lobster Panulirus argus.Journal of molecular neuroscience : MN · 2009Article
- Context dependence of proneural bHLH proteins.Current opinion in genetics & development · 2008Review
- Transcriptional selectors, masters, and combinatorial codes: regulatory principles of neural subtype specification.Wiley interdisciplinary reviews. Developmental biologyReview
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Abstract
Using the well-characterised paradigm of Drosophila sensory nervous system development, we examine the functional distinctness of the Amos and Atonal (Ato) proneural transcription factors, which have different mutant phenotypes but share very high similarity in their signature bHLH domains. Using misexpression and mutant rescue assays, we show that Ato and Amos proteins have abundantly distinct intrinsic proneural capabilities in much of the ectoderm. The eye, however, is an exception: here both proteins share the capability to direct the R8 photoreceptor fate choice. Therefore, functional distinctness between these closely related transcription factors vary with developmental context, indicating different molecular mechanisms of specificity in different contexts. Consistent with this, the structural basis for their distinctness also varies depending upon the function in question. In previous studies of neural bHLH factors, specificity invariably mapped to the bHLH domain sequence. Similarly, and despite their high similarity, much of the Amos' specificity relative to Ato maps to Amos-specific residues in its bHLH domain. For Ato-specific functions, however, the Amos bHLH domain can substitute for that of Ato. Consequently, Ato's specificity relative to Amos requires the non-bHLH portion of the Ato protein. Ato provides a powerful precedence for a role of non-bHLH sequences in modulating bHLH functional specificity. This has implications for structural and functional comparisons of other closely related transcription factors, and for understanding the molecular basis of specificity.
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