Evidence map›Paper›PMID 17709118›Full record

ArticleMathematical biosciences2007

A stochastic model of immune-modulated malaria infection and disease in children.

David Gurarie, F Ellis McKenzie

Open access · greenAbstract read
In one paragraph

Article in Mathematical biosciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David GurarieDepartment of Mathematics, Case Western Reserve University, Cleveland, OH 44106, USA. David.Gurarie@case.edu
F Ellis McKenzie
Case Western Reserve University · USFogarty International Center · US

Funding

HUMAN POPULATION GROWTH IMPACT ON S. HAEMATOBIUMR01TW001543 · FIC · CASE WESTERN RESERVE UNIVERSITY · PI KING, CHARLES HARDING · 2000 to 2005
$2.1M
FIC NIH HHS R01 TW001543Intramural NIH HHS Z99 TW999999
6 · The paper itself

Abstract

We develop a simple three-state stochastic description of individual malaria infections that relates dynamics of disease and immune status to age and previous exposure, under different intensities of transmission. We apply the resulting individual-based community models to examine the effects of drug treatment and vaccination on the frequency and severity of disease in ensembles of children. The several broad qualitative similarities between our results and field observations include potential rebound effects following intervals of drug treatment.

Indexed as

Models, ImmunologicalAge FactorsAnimalsChildChild, PreschoolHumansInfantInsect VectorsMalariaMalaria VaccinesMarkov ChainsNumerical Analysis, Computer-AssistedPlasmodiumStochastic ProcessesMalaria Vaccines

Identifiers

PMID17709118
PMCPMC2173879
OpenAlexW2046988584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.