ArticleExperimental parasitology2008
Schistosoma mansoni: the dicer gene and its expression.
Article in Experimental parasitology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Circulatory microRNAs: promising non-invasive prognostic and diagnostic biomarkers for parasitic infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Review
- Which Plant Proteins Are Involved in Antiviral Defense? Review on In Vivo and In Vitro Activities of Selected Plant Proteins against Viruses.International journal of molecular sciences · 2017Review
- Application of RNAi to Genomic Drug Target Validation in Schistosomes.PLoS neglected tropical diseases · 2015Article
- A novel Schistosoma japonicum endonuclease homologous to DNase II.BMC genomics · 2015Article
- A novel mechanism underlies caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease during apoptosis.Cell research · 2014Article
- Role of microRNAs in schistosomes and schistosomiasis.Frontiers in cellular and infection microbiology · 2014Review
- Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible role in sex chromosome emergence.Genome biology · 2012Article
- Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery.Trends in parasitology · 2011Review
- Progress with schistosome transgenesis.Memorias do Instituto Oswaldo Cruz · 2011Review
- Polyethyleneimine (PEI) mediated siRNA gene silencing in the Schistosoma mansoni snail host, Biomphalaria glabrata.PLoS neglected tropical diseases · 2011Article
- Schistosoma mansoni U6 gene promoter-driven short hairpin RNA induces RNA interference in human fibrosarcoma cells and schistosomules.International journal for parasitology · 2011Article
- Identification of Schistosoma mansoni microRNAs.BMC genomics · 2011Article
- Vector-based RNA interference of cathepsin B1 in Schistosoma mansoni.Cellular and molecular life sciences : CMLS · 2010Article
- RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening.PLoS neglected tropical diseases · 2010Article
- Analysis and characterization of the genes encoding the Dicer and Argonaute proteins of Schistosoma japonicum.Parasites & vectors · 2010Article
- MicroRNAs of parasites: current status and future perspectives.Parasitology research · 2010Review
- RNA interference in schistosomes: machinery and methodology.Parasitology · 2010Article
- In vitro manipulation of gene expression in larval Schistosoma: a model for postgenomic approaches in Trematoda.Parasitology · 2010Review
- Genome-wide identification of Schistosoma japonicum microRNAs using a deep-sequencing approach.PloS one · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RNA interference (RNAi) is a gene silencing mechanism that plays an important role in regulating gene expression in many eukaryotes and has become a valuable molecular tool for analyzing gene function. Multi-domain nucleases called Dicer proteins play pivotal roles in RNAi. In this paper, we characterize the structure and expression of the Dicer gene from the platyhelminth parasite Schistosoma mansoni. The gene (SmDicer) is over 54kb long and comprises 30 exons that potentially encode a 2641 amino acid protein. This is the largest Dicer protein yet described. SmDicer contains all domains that are characteristic of metazoan dicers including an amino terminal helicase domain, DUF283, a PAZ domain, two RNAse III domains and an RNA binding domain. An examination of the available S. mansoni genome sequence suggests that the Dicer gene described here is the only Dicer gene in the parasite genome. SmDicer is expressed throughout schistosome development suggesting that RNAi technologies might be employed in deciphering gene function in all life stages of this parasite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.