Evidence map›Paper›PMID 17707624›Full record

ReviewCurrent opinion in immunology2007

Retroviral proteins that interact with the host cell cytoskeleton.

Mojgan H Naghavi, Stephen P Goff

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Stable microtubule subsets facilitate early HIV-1 infection.AIDS research and human retroviruses · 2014
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Mojgan H NaghaviSchool of Medicine and Medical Science, Center for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland.
Stephen P Goff
Howard Hughes Medical Institute · USUniversity College Dublin · IE

Funding

CONSTRUCTION AND ANALYSIS OF RETROVIRUS MUTANTSR37CA030488 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GOFF, STEPHEN PAINE · 1990 to 2013
$2.2M
NCI NIH HHS R37 CA030488
6 · The paper itself

Abstract

In the past decade, several lines of evidence have highlighted the importance of the host cell cytoskeleton in various stages of retroviral infection. To complete their lifecycle, retroviruses must penetrate the outer barrier of the cell membrane, and viral cores containing the viral genome must traverse the cytoplasm to the nucleus and then viral gene products must make the journey back to the cell surface in order to release new progeny. The presence of a dense cytoskeletal network and organelles in the cytoplasm creates an environment that greatly impedes diffusion of macromolecules such as viruses. As such, retroviruses have evolved means to hijack actin as well as microtubule cytoskeletal networks that regulate macromolecular movement within the host cell. Developing studies are discovering several host and viral factors that play important roles in retroviral trafficking.

Indexed as

AnimalsCytoskeletal ProteinsCytoskeletonHIVHIV InfectionsHumansMicrotubulesnef Gene Products, Human Immunodeficiency VirusProtein TransportRetroviridaeRetroviridae InfectionsVirus AssemblyVirus IntegrationVirus ReplicationCytoskeletal Proteinsnef Gene Products, Human Immunodeficiency Virusnef protein, Human immunodeficiency virus 1

Identifiers

PMID17707624
PMCPMC2040053
OpenAlexW1969331835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.