Evidence map›Paper›PMID 17707545›Full record

ReviewAdvanced drug delivery reviews2007

"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery?

L K Medina-Kauwe

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Caveolae as Potential Hijackable Gates in Cell Communication.Frontiers in cell and developmental biology · 2020
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Internalization of the Active Subunit of theFrontiers in cellular and infection microbiology · 2017
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease.Nanomedicine : nanotechnology, biology, and medicine · 2012
    Review
  14. Review
  15. Action and reaction: the biological response to siRNA and its delivery vehicles.Molecular therapy : the journal of the American Society of Gene Therapy · 2012
    Review
  16. Non-degradative intracellular trafficking of highly compacted polymeric DNA nanoparticles.Journal of controlled release : official journal of the Controlled Release Society · 2012
    Article
  17. Article
  18. Article
  19. Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes.Journal of controlled release : official journal of the Controlled Release Society · 2008
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

L K Medina-KauweMedinaL@cshs.org

Funding

Heregulin-Targeted Protein Uptake for Breast CancerR01CA102126 · NCI · CEDARS-SINAI MEDICAL CENTER · PI MEDINA-KAUWE, LALI K · 2003 to 2006
$983k
A NOVEL TARGETED THERAPEUTIC USING VIRAL CAPSID PROTEINR21CA116014 · NCI · CEDARS-SINAI MEDICAL CENTER · PI MEDINA-KAUWE, LALI K · 2007 to 2008
$350k
NCI NIH HHS R01 CA102126NCI NIH HHS R21 CA116014
6 · The paper itself

Abstract

Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway. Retrograde transport and caveolar uptake are among the better characterized pathways, as alternatives to clathrin-mediated endocytosis, that are known to facilitate entry of pathogens and potential delivery agents. Recent characterization of the trafficking mechanisms of prion proteins and certain bacteria may present new paradigms for strategizing improvements in therapeutic spread and retention of therapy. This review will provide an overview of such endocytic pathways, and discuss current and future possibilities in using these routes as a means to improve therapeutic delivery.

Indexed as

Drug Delivery SystemsAnimalsBacterial ToxinsBiological TransportCaveolaeClathrinClathrin-Coated VesiclesCoated Pits, Cell-MembraneEndocytosisEndoplasmic ReticulumEndosomesGolgi ApparatusIntracellular Signaling Peptides and ProteinsPrionsToxins, Biologicaltrans-Golgi NetworkBacterial ToxinsClathrinIntracellular Signaling Peptides and ProteinsPrionsToxins, BiologicalVesicular Transport Proteins

Identifiers

PMID17707545
PMCPMC2040389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.