ArticleBiomaterials2007
Targeted binding of PLA microparticles with lipid-PEG-tethered ligands.
Article in Biomaterials, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Poly(lactide)-Based Materials Modified with Biomolecules: A Review.Materials (Basel, Switzerland) · 2024Review
- Impact of ConcanavalinA affinity in the intracellular fate of Protein Corona on Glucosamine Au nanoparticles.Scientific reports · 2018Article
- Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules.Biomacromolecules · 2018Article
- Watching the gorilla and questioning delivery dogma.Journal of controlled release : official journal of the Controlled Release Society · 2017Review
- Microencapsulation of Live Cells in Synthetic Polymer Capsules.ACS omega · 2017Article
- Cryo-electron tomography investigation of serum albumin-camouflaged tobacco mosaic virus nanoparticles.Nanoscale · 2017Article
- Lecithin and PLGA-based self-assembled nanocomposite, Lecithmer: preparation, characterization, and pharmacokinetic/pharmacodynamic evaluation.Drug delivery and translational research · 2016Article
- PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway.International journal of nanomedicine · 2015Article
- Folate-modified lipid-polymer hybrid nanoparticles for targeted paclitaxel delivery.International journal of nanomedicine · 2015Article
- Biodegradable polymeric microsphere-based vaccines and their applications in infectious diseases.Human vaccines & immunotherapeutics · 2015Review
- High-relaxivity superparamagnetic iron oxide nanoworms with decreased immune recognition and long-circulating properties.ACS nano · 2014Article
- Article
- Multimodal delivery of irinotecan from microparticles with two distinct compartments.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- A review of combined experimental and computational procedures for assessing biopolymer structure-process-property relationships.Biomaterials · 2012Review
- PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics.Nano letters · 2012Article
- Different effect of hydrogelation on antifouling and circulation properties of dextran-iron oxide nanoparticles.Molecular pharmaceutics · 2012Article
- Use of lectin-functionalized particles for oral immunotherapy.Therapeutic delivery · 2012Review
- Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides.Biomaterials · 2011Article
- Nanoparticle PEGylation for imaging and therapy.Nanomedicine (London, England) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Solid core polymeric particles are an attractive delivery vehicle as they can efficiently encapsulate drugs of different physical and chemical characteristics. However, the effective targeting of such particles for therapeutic purposes has been somewhat elusive. Here, we report novel polymeric particles comprised of poly(lactic acid) (PLA) with incorporated poly(ethylene glycol)-lipids (PEG-lipids). Particles are characterized for morphology, surface charge, and composition with field-emission scanning electron microscopy (FESEM), zeta potential measurements, and proton nuclear magnetic resonance ((1)H NMR) spectroscopy, respectively. The surface densities of PEG lipids determined by (1)H NMR and particle size distributions are consistent with scaling theory for adsorption of chains onto a surface. We observe significant binding of liganded PEG-lipid tethers when the molecular weight is greater than the unliganded PEG-lipids for significant binding events. Importantly, the binding is not completely lost when the unliganded PEG molecular weight is greater than the liganded PEG-lipid tether. We observe a similar trend for the lower affinity ligand (thioctic acid), but the degree of binding is significantly lower than the high affinity ligand (biotin). This novel technique used to fabricate these liganded particles combined with the lipid bilayer binding studies provides a platform for systematic optimization of particle binding.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.