ArticleJournal of the American College of Cardiology2007
The association of differing measures of overweight and obesity with prevalent atherosclerosis: the Dallas Heart Study.
Article in Journal of the American College of Cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03038620 (Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease), which is not on this map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease
Who cites it
64 citing papers in PubMed, 163 citations in OpenAlex.
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- Trial
- Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression: Meta-Analysis of 68,629 Participants.JACC. Advances · 2026Article
- The association between visceral adiposity index and long-term all-cause mortality shows age-related disparities: a nationwide cohort study.BMC public health · 2025Article
- Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis.Journal of atherosclerosis and thrombosis · 2024Article
- Urinary cortisol and cardiovascular events in women vs. men: The multi-ethnic study of atherosclerosis.American heart journal plus : cardiology research and practice · 2023Article
- How does obesity affect mortality through blood pressure and blood glucose in Chinese and US citizens? Insights from a causal mediation analysis of two large cohorts.Journal of global health · 2023Article
- BMI is not independently associated with coronary artery calcification in a large single-center CT cohort.Obesity science & practice · 2023Article
- Associations between Body Mass Index, Waist Circumference, and Myocardial Infarction in Older Adults Aged over 75 Years: A Population-Based Cohort Study.Medicina (Kaunas, Lithuania) · 2022Article
- Association Between a Body Shape Index and Subclinical Carotid Atherosclerosis in Population Free of Cardiovascular and Cerebrovascular Diseases.Journal of atherosclerosis and thrombosis · 2022Article
- Is Obesity a Risk Factor for Carotid Atherosclerotic Disease?-Opportunistic Review.Journal of cardiovascular development and disease · 2022Review
- A Bibliometric Analysis of Research on the Links Between Gut Microbiota and Atherosclerosis.Frontiers in cardiovascular medicine · 2022Article
- Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association.Circulation · 2021Review
- Influence of Waist-to-Hip Ratio on the Prognosis of Heart Failure Patients With Revascularized Coronary Heart Disease.Frontiers in cardiovascular medicine · 2021Article
- Endurance exercise and the risk of cardiovascular pathology in men: a comparison between lifelong and late-onset endurance training and a non-athletic lifestyle - rationale and design of the Master@Heart study, a prospective cohort trial.BMJ open sport & exercise medicine · 2021Article
- Association between anthropometric indicators of obesity and cardiovascular risk factors among adults in Shanghai, China.BMC public health · 2019Article
- Central and peripheral pulse wave velocity and subclinical myocardial stress and damage in older adults.PloS one · 2019Article
- Assessment of adiposity distribution and its association with diabetes and insulin resistance: a population-based study.Diabetology & metabolic syndrome · 2019Article
- Obesity and metabolic features associated with long-term developing diastolic dysfunction in an initially healthy population-based cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThis study sought to evaluate the associations between different measures of obesity and prevalent atherosclerosis in a large population-based cohort.
backgroundAlthough obesity is associated with cardiovascular mortality, it is unclear whether this relationship is mediated by increased atherosclerotic burden.
methodsUsing data from the Dallas Heart Study, we assessed the association between gender-specific obesity measures (i.e., body mass index [BMI]; waist circumference [WC]; waist-to-hip ratio [WHR]) and prevalent atherosclerosis defined as coronary artery calcium (CAC) score >10 Agatston units measured by electron-beam computed tomography and detectable aortic plaque measured by magnetic resonance imaging.
resultsIn univariable analyses (n = 2,744), CAC prevalence was significantly greater only in the fifth versus first quintile of BMI, whereas it increased stepwise across quintiles of WC and WHR (p trend <0.001 for each). After multivariable adjustment for standard risk factors, prevalent CAC was more frequent in the fifth versus first quintile of WHR (odds ratio 1.91, 95% confidence interval 1.30 to 2.80), whereas no independent positive association was observed for BMI or WC. Similar results were observed for aortic plaque in both univariable and multivariable-adjusted analyses. The c-statistic for discrimination of prevalent CAC was greater for WHR compared with BMI and WC in women and men (p < 0.001 vs. BMI; p < 0.01 vs. WC).
conclusionsWe discovered that WHR was independently associated with prevalent atherosclerosis and provided better discrimination than either BMI or WC. The associations between obesity measurements and atherosclerosis mirror those observed between obesity and cardiovascular mortality, suggesting that obesity contributes to cardiovascular mortality via increased atherosclerotic burden.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.