ArticleThe Journal of surgical research2008
Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation.
Article in The Journal of surgical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Recurrent BMP4 variants in exon 4 cause non-HFE-associated hemochromatosis via the BMP/SMAD signaling pathway.Orphanet journal of rare diseases · 2024Article
- Article
- BMPER Improves Vascular Remodeling and the Contractile Vascular SMC Phenotype.International journal of molecular sciences · 2023Article
- Angioplasty induces epigenomic remodeling in injured arteries.Life science alliance · 2022Article
- Article
- Medial artery calcification increases neointimal hyperplasia after balloon injury.Scientific reports · 2019Article
- Increased Risk of Heterotopic Ossification Following Revision Hip Arthroplasty for Periprosthetic Joint Infection.The archives of bone and joint surgery · 2018Article
- Endothelial BMP4 Regulates Leukocyte Diapedesis and Promotes Inflammation.Inflammation · 2017Article
- Bone Morphogenetic Protein-Modulator BMPER Regulates Endothelial Barrier Function.Inflammation · 2017Article
- Differential gene expression by endothelial cells under positive and negative streamwise gradients of high wall shear stress.American journal of physiology. Cell physiology · 2013Article
- BMP4 is a novel paracrine inhibitor of liver regeneration.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Palmitate promotes the paracrine effects of macrophages on vascular smooth muscle cells: the role of bone morphogenetic proteins.PloS one · 2012Article
- BMPs and their clinical potentials.BMB reports · 2011Review
- Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification.Circulation research · 2010Article
- BMP signaling in vascular development and disease.Cytokine & growth factor reviews · 2010Review
- Article
- Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling.The Journal of biological chemistry · 2009Article
- BMP type I receptor inhibition reduces heterotopic [corrected] ossification.Nature medicine · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily of proteins that have multiple functional roles in mammalian development. A role for BMP4 in adult vascular remodeling has recently been suggested. We evaluated the expression of Bmp4 during neointimal lesion development in vivo. MATERIALS AND
methodsHeterozygous Bmp4(lacZ/+) mice were used to evaluate in vivo Bmp4 expression after carotid ligation. beta-galactosidase (beta-gal) activity was evaluated in histological sections 1 to 14 d after carotid ligation and this was compared with control carotid arteries. The effects of recombinant human (rh) BMP4 on smooth muscle cell (SMC) migration and proliferation were evaluated using a rat aortic SMC line. We next assessed the effects of BMP4 signaling by over-expressing a constitutively active BMP receptor (BMPR-IA/Alk-3) using adenovirus-mediated gene transfer. SMC proliferation, migration, and apoptosis were evaluated in adenovirus transfected cells.
resultsLigated carotid arteries expressed endothelium-specific beta-gal staining after 1 d. Staining intensity increased at both 3 d and 1 wk after ligation and remained stable at 2 weeks while no beta-gal staining was observed in control vessels. Endothelial-specific expression of beta-galactosidase was confirmed through positive staining for PECAM-1. When human recombinant BMP4 was added to cultured SMCs, it inhibited migration but did not affect cultured SMC proliferation. SMCs infected with adenovirus encoding for the active BMP receptor Alk-3 demonstrated dose-dependent receptor expression. Alk-3 over-expressing cells showed a dose-dependent decrease in proliferation and migration but no effect on apoptosis.
conclusionsThese results demonstrate that endothelial Bmp4 expression is upregulated after carotid ligation in vivo, and furthermore, that activating the BMP signaling cascade results in decreased SMC proliferation and migration. This suggests that BMPs may counterbalance the effect of mitogen up-regulation observed during the development of neointimal hyperplasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.