ReviewExperimental neurology2008
Molecular/genetic manipulation of extrinsic axon guidance factors for CNS repair and regeneration.
Review in Experimental neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Advanced rehabilitation in ischaemic stroke research.Stroke and vascular neurology · 2024Review
- Transcriptomic and bioinformatics analysis of the mechanism by which erythropoietin promotes recovery from traumatic brain injury in mice.Neural regeneration research · 2024Article
- Biomaterial and tissue-engineering strategies for the treatment of brain neurodegeneration.Neural regeneration research · 2022Review
- Review
- Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling.Journal of visualized experiments : JoVE · 2017Article
- Δ9-Tetrahydrocannabinol (Δ9-THC) Promotes Neuroimmune-Modulatory MicroRNA Profile in Striatum of Simian Immunodeficiency Virus (SIV)-Infected Macaques.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- Article
- Rebuilding Brain Circuitry with Living Micro-Tissue Engineered Neural Networks.Tissue engineering. Part A · 2015Article
- Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter.Neuroscience · 2013Article
- Article
- Microtissue engineered constructs with living axons for targeted nervous system reconstruction.Tissue engineering. Part A · 2012Article
- Plasticity after spinal cord injury: relevance to recovery and approaches to facilitate it.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
- Construction of pathways to promote axon growth within the adult central nervous system.Brain research bulletin · 2011Review
- Article
- Modality-specific axonal regeneration: toward selective regenerative neural interfaces.Frontiers in neuroengineering · 2011Article
- Spatially patterned gene expression for guided neurite extension.Journal of neuroscience research · 2009Article
- Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.Trends in neurosciences · 2009Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During development, guidance molecules play a key role in the formation of complex circuits required for neural functions. With the cessation of development, this exuberant growth process slows and stabilizes, and inhibitory molecules expressed by glia prevent initial attempts for axonal regeneration. In this review, we discuss the expression patterns and relative contribution of several guidance molecules on the regenerative process. Injury to the immature CNS or species capable of regenerating exhibit a complete or partial recapitulation of their developmental guidance patterns, whereas similar injuries to adult mammals results in altered expression that acts to further hinder regeneration. Manipulations of guidance molecules after injury have been used to control detrimental effects of axon sprouting and target regenerating axons within the spinal cord.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.