ArticleFertility and sterility2008
Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriage.
Article in Fertility and sterility, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Decreased Production of TNF-α and IL-6 Inflammatory Cytokines in Non-Pregnant Idiopathic RPL Women Immunomodulatory Effect of Sildenafil Citrate on the Cellular Response of Idiopathic RPL Women.Journal of clinical medicine · 2021Article
- Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure.The Korean journal of internal medicine · 2019Observational
- Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage - a pilot study.Reproductive biology and endocrinology : RB&E · 2018Article
- The impact of female fetal sex on preeclampsia and the maternal immune milieu.Pregnancy hypertension · 2018Article
- Active Immunisation with Partner Lymphocytes in Female Patients Who Want to Become Pregnant - Current Status.Geburtshilfe und Frauenheilkunde · 2018Article
- First and second trimester immune biomarkers in preeclamptic and normotensive women.Pregnancy hypertension · 2016Article
- Case-control data analysis for randomly pooled biomarkers.Biometrical journal. Biometrische Zeitschrift · 2016Article
- Positing, fitting, and selecting regression models for pooled biomarker data.Statistics in medicine · 2015Article
- Urinary cytokine and chemokine profiles across the menstrual cycle in healthy reproductive-aged women.Fertility and sterility · 2014Article
- Regression for skewed biomarker outcomes subject to pooling.Biometrics · 2014Article
- Assessment of skewed exposure in case-control studies with pooling.Statistics in medicine · 2012Article
- Early elevations of the complement activation fragment C3a and adverse pregnancy outcomes.Obstetrics and gynecology · 2011Article
- Treatment of batch in the detection, calibration, and quantification of immunoassays in large-scale epidemiologic studies.Epidemiology (Cambridge, Mass.) · 2010Article
- Assays with lower detection limits: implications for epidemiological investigations.Paediatric and perinatal epidemiology · 2008Article
- Interleukin-6 in pregnancy with sickle cell disease.Hematology, transfusion and cell therapyArticle
- Maternal serum granulocyte colony-stimulating factor levels and spontaneous preterm birth.Journal of women's health (2002)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the hypothesis that cytokine levels are associated with miscarriage risk using serum samples collected before report of miscarriage.
designA nested case-control study.
settingBiospecimens from the multisite Collaborative Perinatal Project, University of Florida, laboratory assessment of interleukin (IL)-1 receptor antagonist, IL-1beta, IL-4, IL-6, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, thrombopoietin (TPO), and granulocyte colony-stimulating factor (G-CSF). PATIENT(S): Cases of miscarriage (n = 439) were matched to controls (n = 373) by gestational age at sample collection. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Miscarriage. RESULT(S): Increased risk of miscarriage was associated with elevated TPO (adjusted odds ratio [OR] 1.16, 95% confidence interval [CI] 1.00-1.36) and decreased G-CSF (adjusted OR 0.78, 95% CI 0.64-0.95). When analysis was restricted to samples collected more than 35 days before miscarriage, the effect of G-CSF was not observed (adjusted OR 0.96, 95% CI 0.72-1.28), whereas increased risk related to higher TPO remained. CONCLUSION(S): Circulating levels of TPO may be associated with increased risk of miscarriage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.