Evidence map›Paper›PMID 17704975›Full record

Trial reportWiener medizinische Wochenschrift (1946)2007

Effects of Ginkgo biloba extract EGb 761 on neuropsychiatric symptoms of dementia: findings from a randomised controlled trial.

Andrey Scripnikov, Alexander Khomenko, Oleksandr Napryeyenko, GINDEM-NP Study Group

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Wiener medizinische Wochenschrift (1946), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 8 pooled it
14.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 8 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Pharmacotherapies for sleep disturbances in dementia.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pharmacotherapies for sleep disturbances in dementia.The Cochrane database of systematic reviews · 2016
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Ginkgo biloba for cognitive impairment and dementia.The Cochrane database of systematic reviews · 2009
    Pooled it
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Ginkgo biloba induced mood dysregulation: a case report.BMC complementary and alternative medicine · 2018
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andrey ScripnikovPoltava Regional Psychiatry Hospital, Poltava, Ukraine.
Alexander Khomenko
Oleksandr Napryeyenko
GINDEM-NP Study Group
Kyiv City Clinical Oncology Center · UAPoltava Regional Institute of Postgraduate Education · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a randomised, double-blind, 22-week trial 400 patients with dementia associated with neuropsychiatric features were treated with Ginkgo biloba extract EGb 761 (240 mg/day) or placebo. Patients with probable Alzheimer's disease, possible Alzheimer's disease with cerebrovascular disease or vascular dementia were eligible if they scored 9 to 23 on the SKT cognitive test battery and at least 5 on the Neuropsychiatric Inventory (NPI). EGb 761 was significantly superior to placebo with respect to the primary (SKT test battery) and all secondary outcome variables. The mean composite score (frequency x severity) and the mean caregiver distress score of the NPI dropped from 21.3 to 14.7 and 13.5 to 8.7, respectively, in the EGb 761-treated patients, but increased from 21.6 to 24.1 and 13.4 to 13.9, respectively, under placebo (p < 0.001). The largest drug-placebo differences in favour of EGb 761 were found for apathy/indifference, anxiety, irritability/lability, depression/dysphoria and sleep/nighttime behaviour.

Indexed as

Ginkgo bilobaPhytotherapyAgedAlzheimer DiseaseCardiovascular AgentsDementiaDementia, VascularDouble-Blind MethodGeriatric AssessmentGinkgo ExtractHumansMiddle AgedNeuropsychological TestsPlant ExtractsTime FactorsTreatment OutcomeCardiovascular AgentsGinkgo biloba extractGinkgo ExtractPlant Extracts

Identifiers

PMID17704975
OpenAlexW1514206567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.