ArticleInternational journal of colorectal disease2008
Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients.
Article in International journal of colorectal disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Correlation Between DCAMKL-1 Protein Expression and K-ras Gene Mutation in Colorectal Cancer.Cancer management and research · 2024Article
- Construction of prediction model for KRAS mutation status of colorectal cancer based on CT radiomics.Japanese journal of radiology · 2023Article
- Postoperative Circulating Tumor DNA Can Predict High Risk Patients with Colorectal Cancer Based on Next-Generation Sequencing.Cancers · 2021Article
- Transmission Jeopardy of Adenomatosis Polyposis Coli and Methylenetetrahydrofolate Reductase in Colorectal Cancer.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2021Article
- Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer.OncoTargets and therapy · 2020Article
- Prevalence and risk factors of colorectal cancer in Asia.Intestinal research · 2019Review
- Comparison of microsatellite status detection methods in colorectal carcinoma.International journal of clinical and experimental pathology · 2018Article
- Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system.British journal of cancer · 2017Article
- Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?Trends in cancer · 2017Review
- Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Validation of specificity of antibodies for immunohistochemistry: the case of ROR2.Virchows Archiv : an international journal of pathology · 2017Article
- Molecular spectrum ofJournal of gastrointestinal oncology · 2016Article
- Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer.Disease markers · 2016Article
- KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients.World journal of gastroenterology · 2015Article
- Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer.Cell journal · 2014Article
- Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer.Oncology letters · 2012Article
- Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population.Human genomics · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimColorectal cancer (CRC) is one of the most rapidly increasing cancers in Korea, but no comprehensive analysis has been performed to speculate the genetic basis of CRC development. We investigated the presence of adenomatous polyposis coli gene (APC), Kirsten-ras (K-ras), p53, microsatellite instability (MSI), and melanoma antigen gene (MAGE) alterations in CRC and correlated the results obtained with clinical data. MATERIALS AND
methodsWe collected 78 cancer tissues from CRC patients. Genetic analyses were performed on APC, K-ras, p53, and MSI (BAT 25 and BAT 26), and in addition, MAGE expression was tested by reverse transcription polymerase chain reaction. Correlations between genetic markers and clinical factors were analyzed after reviewing medical records.
resultThe positive rates for alterations of APC, K-ras, p53, MSI, and MAGE in 78 tissue samples were 33.3, 29.5, 34.6, 9.0, and 68.4%, respectively. Mutations were frequently detected in codons 1291 and 1450 of APC, in codon 12 of K-ras and in codons 248, 282, and 176 of p53. APC mutations were frequently noted in early-stage cancer, whereas MSI was observed in right-sided and multiple cancers. No associations were found between the presence of alterations in APC, K-ras, p53, MSI, and MAGE.
interpretationIn Koreans, positive rates of alterations in APC and p53 were slightly lower than those of APC and p53 in Caucasians, and the genetic alterations including MAGE expression are involved in 92.1% of CRCs. The lack of multiple mutations and of a relation between mutation rates and clinical stage suggest that genetic alterations might have independent influences on CRC development in Koreans.
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