ArticlePlant physiology2007
Transcriptional profiling of high pigment-2dg tomato mutant links early fruit plastid biogenesis with its overproduction of phytonutrients.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 163 citations in OpenAlex.
- Tomato Leaf Color Diversity as a Functional Trait: Molecular Mechanisms, Physiological Significance, and Environmental Responses.International journal of molecular sciences · 2026Review
- Metabolism and regulation of chlorophyll and carotenoids in tomato fruits.Horticulture research · 2026Article
- The carotenoids metabolism during tomato fruit ripening: insights into multi-level regulatory network.BMC plant biology · 2026Review
- Enhancing secondary metabolite accumulation in medicinal plants to improve immunomodulatory activity.Frontiers in pharmacology · 2026Review
- Proteome and Phosphoproteome of Tomato Fruit Identify REDUCED CHLOROPLAST COVERAGE 1a as A Ripening Regulator.Genomics, proteomics & bioinformatics · 2025Article
- Manipulating the Light Systemic Signal HY5 Greatly Improve Fruit Quality in Tomato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Marker assisted early generation identification of root knot disease resistant orange tomato segregants with multiple desirable alleles.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Genetic mapping of a single nuclear locus determines the white flesh color in watermelon (Frontiers in plant science · 2023Article
- Biochemical Characterization of Orange-Colored Rice Calli Induced by Target Mutagenesis ofPlants (Basel, Switzerland) · 2022Article
- Fruit ripening: dynamics and integrated analysis of carotenoids and anthocyanins.BMC plant biology · 2022Review
- Coordinated transcriptional regulation of the carotenoid biosynthesis contributes to fruit lycopene content in high-lycopene tomato genotypes.Horticulture research · 2022Article
- Phenotypic Characterization of High Carotenoid Tomato Mutants Generated by the Target-AID Base-Editing Technology.Frontiers in plant science · 2022Article
- Review
- Skin colour, carotenogenesis and chlorophyll degradation mutant alleles: genetic orchestration behind the fruit colour variation in tomato.Plant cell reports · 2021Review
- Enhanced Reproductive Thermotolerance of the TomatoFrontiers in plant science · 2021Article
- Shoot Regeneration Is Not a Single Cell Event.Plants (Basel, Switzerland) · 2020Article
- Development of zeaxanthin-rich tomato fruit through genetic manipulations of carotenoid biosynthesis.Plant biotechnology journal · 2020Article
- Beyond the limits of photoperception: constitutively active PHYTOCHROME B2 overexpression as a means of improving fruit nutritional quality in tomato.Plant biotechnology journal · 2020Article
- Progress on Understanding Transcriptional Regulation of Chloroplast Development in Fleshy Fruit.International journal of molecular sciences · 2020Review
- SlMYB72 Regulates the Metabolism of Chlorophylls, Carotenoids, and Flavonoids in Tomato Fruit.Plant physiology · 2020Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotypes of the tomato (Solanum lycopersicum) high pigment-2(dg) (hp-2(dg)) and hp-2(j) mutants are caused by lesions in the gene encoding DEETIOLATED1, a negative regulator of light signaling. Homozygous hp-2(dg) and hp-2(j) plants display a plethora of distinctive developmental and metabolic phenotypes in comparison to their normal isogenic counterparts. These mutants are, however, best known for the increased levels of carotenoids, primarily lycopene, and other plastid-accumulating functional metabolites. In this study we analyzed the transcriptional alterations in mature-green, breaker, and early red fruits of hp-2(dg)/hp-2(dg) plants in relation to their normal counterparts using microarray technology. Results show that a large portion of the genes that are affected by hp-2(dg) mutation display a tendency for up- rather than down-regulation. Ontology assignment of these differentially regulated transcripts revealed a consistent up-regulation of transcripts related to chloroplast biogenesis and photosynthesis in hp-2(dg) mutants throughout fruit ripening. A tendency of up-regulation was also observed in structural genes involved in phytonutrient biosynthesis. However, this up-regulation was not as consistent, positioning plastid biogenesis as an important determinant of phytonutrient overproduction in hp-2(dg) and possibly other hp mutant fruits. Microscopic observations revealed a highly significant increase in chloroplast size and number in pericarp cells of mature-green hp-2(dg)/hp-2(dg) and hp-2(j)/hp-2(j) fruits in comparison to their normal counterparts. This increase could be observed from early stages of fruit development. Therefore, the molecular trigger that drives phytonutrient overproduction in hp-2(dg) and hp-2(j) mutant fruits should be initially traced at these early stages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.