ArticleBiophysical journal2007
The molecular mechanism of monolayer-bilayer transformations of lung surfactant from molecular dynamics simulations.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- How sighing regulates pulmonary surfactant structure and its role in breathing mechanics.Science advances · 2025Article
- Martini compatible coarse-grained model of polyethylenimine for pulmonary gene delivery.Scientific reports · 2025Article
- Drug Meets Monolayer: Understanding the Interactions of Sterol Drugs with Models of the Lung Surfactant Monolayer Using Molecular Dynamics Simulations.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Origin of gradients in lipid density and surface tension between connected lipid droplet and bilayer.Biophysical journal · 2021Article
- Understanding the Functional Properties of Lipid Heterogeneity in Pulmonary Surfactant Monolayers at the Atomistic Level.Frontiers in cell and developmental biology · 2020Article
- Adsorption of Phospholipids at the Air-Water Surface.Biophysical journal · 2019Article
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Anisotropic Membrane Curvature Sensing by Amphipathic Peptides.Biophysical journal · 2016Article
- Computational Models of Ventilator Induced Lung Injury and Surfactant Dysfunction.Drug discovery today. Disease models · 2015Article
- Protein modeling and molecular dynamics simulation of the two novel surfactant proteins SP-G and SP-H.Journal of molecular modeling · 2014Article
- The mechanism of collapse of heterogeneous lipid monolayers.Biophysical journal · 2014Article
- A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant.Biochimica et biophysica acta · 2012Article
- Lung surfactant protein SP-B promotes formation of bilayer reservoirs from monolayer and lipid transfer between the interface and subphase.Biophysical journal · 2011Article
- Molecular organization of the tear fluid lipid layer.Biophysical journal · 2010Article
- A theoretical study of diffusional transport over the alveolar surfactant layer.Journal of the Royal Society, Interface · 2010Article
- Influence of surfactant protein C on the interfacial behavior of phosphatidylethanolamine monolayers.European biophysics journal : EBJ · 2009Article
- Physicochemical effects enhance surfactant transport in pulsatile motion of a semi-infinite bubble.Biophysical journal · 2009Article
- Influence of liquid-layer thickness on pulmonary surfactant spreading and collapse.Biophysical journal · 2008Article
- The molecular mechanism of lipid monolayer collapse.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Coarse-grained molecular simulation of diffusion and reaction kinetics in a crowded virtual cytoplasm.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aqueous lining of the lung surface exposed to the air is covered by lung surfactant, a film consisting of lipid and protein components. The main function of lung surfactant is to reduce the surface tension of the air-water interface to the low values necessary for breathing. This function requires the exchange of material between the lipid monolayer at the interface and lipid reservoirs under dynamic compression and expansion of the interface during the breathing cycle. We simulated the reversible exchange of material between the monolayer and lipid reservoirs under compression and expansion of the interface. We used a mixture of dipalmitoyl-phosphatidylcholine, palmitoyl-oleoyl-phosphatidylglycerol, cholesterol, and surfactant-associated protein C as a functional analog of mammalian lung surfactant. In our simulations, the monolayer collapses into the water subphase on compression and forms bilayer folds. On monolayer reexpansion, the material is transferred from the folds back to the interface. The simulations indicate that the connectivity of the bilayer aggregates to the monolayer is necessary for the reversibility of the monolayer-bilayer transformation. The simulations also show that bilayer aggregates are unstable in the air subphase and stable in the water subphase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.