ArticleBiophysical journal2007
Stable stochastic dynamics in yeast cell cycle.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle.iScience · 2020Article
- A hybrid stochastic model of the budding yeast cell cycle.NPJ systems biology and applications · 2020Article
- Article
- A Stochastic Model of the Yeast Cell Cycle Reveals Roles for Feedback Regulation in Limiting Cellular Variability.PLoS computational biology · 2016Article
- Derivation and experimental comparison of cell-division probability densities.Journal of theoretical biology · 2014Article
- Measurement and modeling of transcriptional noise in the cell cycle regulatory network.Cell cycle (Georgetown, Tex.) · 2013Article
- A checkpoints capturing timing-robust Boolean model of the budding yeast cell cycle regulatory network.BMC systems biology · 2012Article
- A model of yeast cell-cycle regulation based on multisite phosphorylation.Molecular systems biology · 2010Article
- Interplay between intrinsic noise and the stochasticity of the cell cycle in bacterial colonies.Biophysical journal · 2010Article
- Exploring the roles of noise in the eukaryotic cell cycle.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
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2 authors.
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Abstract
Chemical reactions in cells are subject to intense stochastic fluctuations. An important question is how the fundamental physiological behavior of the cell is kept stable against those noisy perturbations. In this study, a stochastic model of the cell cycle of budding yeast was constructed to analyze the effects of noise on the cell-cycle oscillation. The model predicts intense noise in levels of mRNAs and proteins, and the simulated protein levels explain the observed statistical tendency of noise in populations of synchronous and asynchronous cells. Despite intense noise in levels of proteins and mRNAs, the cell cycle is stable enough to bring the largely perturbed cells back to the physiological cyclic oscillation. The model shows that consecutively appearing fixed points are the origin of this stability of the cell cycle.
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