ArticleNucleic acids research2007
A facilitated tracking and transcription mechanism of long-range enhancer function.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 85 citations in OpenAlex.
- Engineering the Link: From Genome Interaction Maps to Functional Insight.Advanced biology · 2025Review
- Viral influencers: deciphering the role of endogenous retroviral LTR12 repeats in cellular gene expression.Journal of virology · 2025Review
- Learning Enhancer-Gene associations from Bulk Transcriptomic and Epigenetic Sequencing Data with STITCHIT.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The Blueprint of Logical Decisions in a NF-κB Signaling System.ACS omega · 2024Article
- Simvastatin-Mediated Nrf2 Activation Induces Fetal Hemoglobin and Antioxidant Enzyme Expression to Ameliorate the Phenotype of Sickle Cell Disease.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions.Nucleic acids research · 2022Article
- Integrative analysis of epigenetics data identifies gene-specific regulatory elements.Nucleic acids research · 2021Article
- Super-enhancer mediated regulation of adult β-globin gene expression: the role of eRNA and Integrator.Nucleic acids research · 2021Article
- Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation.Molecular cell · 2019Article
- Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation.Genomics, proteomics & bioinformatics · 2017Review
- Long non-coding RNAs transcribed by ERV-9 LTR retrotransposon act in cis to modulate long-range LTR enhancer function.Nucleic acids research · 2017Article
- Review
- Topologically-associating domains: gene warehouses adapted to serve transcriptional regulation.Transcription · 2016Review
- Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture.Genes · 2015Review
- Demystifying the secret mission of enhancers: linking distal regulatory elements to target genes.Critical reviews in biochemistry and molecular biology · 2015Review
- Chromatin loops as allosteric modulators of enhancer-promoter interactions.PLoS computational biology · 2014Article
- Uncovering enhancer functions using the α-globin locus.PLoS genetics · 2014Review
- An enhancer-blocking element regulates the cell-specific expression of alcohol dehydrogenase 7.Gene · 2014Article
- Chromatin states reveal functional associations for globally defined transcription start sites in four human cell lines.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In the human epsilon-globin gene locus, the HS2 enhancer in the Locus Control Region regulates transcription of the embryonic epsilon-globin gene located over 10 kb away. The mechanism of long-range HS2 enhancer function was not fully established. Here we show that the HS2 enhancer complex containing the enhancer DNA together with RNA polymerase II (pol II) and TBP tracks along the intervening DNA, synthesizing short, polyadenylated, intergenic RNAs to ultimately loop with the epsilon-globin promoter. Guided by this facilitated tracking and transcription mechanism, the HS2 enhancer delivers pol II and TBP to the cis-linked globin promoter to activate mRNA synthesis from the target gene. An insulator inserted in the intervening DNA between the enhancer and the promoter traps the enhancer DNA and the associated pol II and TBP at the insulator site, blocking mid-stream the facilitated tracking and transcription mechanism of the enhancer complex, thereby blocking long-range enhancer function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.