Evidence map›Paper›PMID 17703932›Full record

ReviewCurrent opinion in immunology2007

Alternative mechanisms of immune receptor diversity.

Gary W Litman, Larry J Dishaw, John P Cannon, Robert N Haire, Jonathan P Rast

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Immune diversity in lophotrochozoans, with a focus on recognition and effector systems.Computational and structural biotechnology journal · 2023
    Review
  3. Article
  4. Review
  5. Article
  6. Structure of a tetrameric galectin from Cinachyrella sp. (ball sponge).Acta crystallographica. Section D, Biological crystallography · 2012
    Article
  7. Article
  8. A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  9. Design principles of adaptive immune systems.Nature reviews. Immunology · 2011
    Review
  10. Review
  11. Article
  12. Review
  13. Yeast surface display of lamprey variable lymphocyte receptors.Methods in molecular biology (Clifton, N.J.) · 2011
    Article
  14. Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection.Proceedings of the National Academy of Sciences of the United States of America · 2010
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Extraordinary intraspecific diversity in oyster sperm bindin.Proceedings of the National Academy of Sciences of the United States of America · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gary W LitmanDepartment of Molecular Genetics, All Children's Hospital, 801 Sixth Street South, St. Petersburg, FL 33701, United States. litmang@allkids.org
Larry J Dishaw
John P Cannon
Robert N Haire
Jonathan P Rast

Funding

EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENESR01AI023338 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI LITMAN, GARY WILLIAM · 1985 to 2014
$3.6M
Novel Innate Immune Receptors in ZebrafishR01AI057559 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI LITMAN, GARY WILLIAM · 2005 to 2013
$3.4M
Novel Innate Immune Receptor in ZebrafishR21AI057559 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI LITMAN, GARY WILLIAM · 2004 to 2004
$326k
NIAID NIH HHS AI57559NIAID NIH HHS R01 AI023338NIAID NIH HHS R01 AI057559NIAID NIH HHS R01 AI23338NIAID NIH HHS R21 AI057559
6 · The paper itself

Abstract

Our views of both innate and adaptive immunity have been significantly modified by recent studies of immune receptors and immunity in protostomes, invertebrate deuterostomes, and jawless vertebrates. Extraordinary variation in the means whereby organisms recognize pathogens has been revealed by a series of recent findings, including: novel forms of familiar immune receptors, high genetic polymorphism for new receptor types, germline rearrangement for non-Ig domain receptors, somatic variation of germline-encoded receptors, and unusually complex alternative splicing of genes with both immune and non-immune roles. Collectively, these observations underscore heretofore unrecognized pathways in the evolution of immune recognition and suggest universal processes by which immune systems co-opt and integrate existing cellular mechanisms to effect diverse recognition functions.

Indexed as

AnimalsCell Adhesion MoleculesGene RearrangementGenetic VariationImmunity, InnateInvertebratesLymphocytesReceptors, ImmunologicToll-Like ReceptorsCell Adhesion MoleculesReceptors, ImmunologicToll-Like Receptors

Identifiers

PMID17703932
PMCPMC2065753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.