ReviewDigestive diseases and sciences2008
Cognitive dysfunction in chronic hepatitis C: a review.
Review in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00788918 (Study of Cerebral Function in Patients With Chronic Hepatitis C Infection Before and After Pegylated Interferon Alfa-2a and Ribavirin Therapy), which is not on this map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Cerebral Function in Patients With Chronic Hepatitis C Infection Before and After Pegylated Interferon Alfa-2a and Ribavirin Therapy
Who cites it
61 citing papers in PubMed, 149 citations in OpenAlex.
- Cognitive function does not worsen during long-term low-dose peginterferon therapy in patients with chronic hepatitis C.The American journal of gastroenterology · 2010Trial
- Comparison of persons who died of drug overdoses with and without evidence of hepatitis C, United States, 2019-2024.Drug and alcohol dependence · 2026Article
- Factors Influencing the Use of Mobile Apps and Wearables: Pre- and Post-Surgery Quality of Life Assessment Study.JMIR formative research · 2026Article
- Does HCV treatment completion affect the neurocognitive outcomes in patients on opioid agonist maintenance treatment: A secondary analysis.Indian journal of psychiatry · 2025Article
- Cognitive Impairments in Viral Hepatitis Patients: Causes, Manifestations, and Impact on Quality of Life.Rambam Maimonides medical journal · 2025Review
- Cognitive Performance in Asymptomatic Elderly People with Hepatitis C: The Role of Education.Journal of clinical medicine · 2023Article
- Real-world effectiveness and safety of direct-acting antivirals in hepatitis C virus patients with mental disorders.World journal of gastroenterology · 2023Observational
- Discontinuation due to neuropsychiatric adverse events with efavirenz- and dolutegravir-based antiretroviral therapy: a comparative real-life study.European journal of hospital pharmacy : science and practice · 2022Observational
- Innate immune activation: Parallels in alcohol use disorder and Alzheimer's disease.Frontiers in molecular neuroscience · 2022Review
- Role of hepatitis c virus in hepatocellular carcinoma and neurological disorders: an overview.Frontiers in oncology · 2022Review
- Hepatitis C Virus-Related Central and Peripheral Nervous System Disorders.Brain sciences · 2021Review
- Cognitive impairment in stable Wilson disease across phenotype.Metabolic brain disease · 2021Article
- Neurological and psychiatric effects of hepatitis C virus infection.World journal of gastroenterology · 2021Review
- Article
- Subacute Cognitive Impairment in Individuals With Mild and Moderate COVID-19: A Case Series.Frontiers in neurology · 2021Article
- Patients with Hepatitis C Infection and Normal Liver Function: A Neuropsychological and Neurophysiological Assessment of Cognitive Functions.International journal of hepatology · 2021Article
- Hepatitis C Virus Infection Increases Fatigue in Health Care Workers.Diseases (Basel, Switzerland) · 2020Article
- Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence.Drug and alcohol dependence · 2020Article
- Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity.AIDS (London, England) · 2020Article
- Cognitive Function in Liver Transplantation.Current transplantation reports · 2020Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hepatitis C virus (HCV) is a common blood-borne illness that affects up to 2% of the world's population and almost 4 million Americans. Cognitive impairment, or difficulty with thinking, has become a well-established symptom in persons with end stage liver disease. It was previously assumed that cognitive impairment was a consequence of cirrhosis-associated hepatic encephalopathy. Recent evidence, however, suggests that approximately one-third of people with chronic HCV experience cognitive impairment even in the absence of cirrhosis and that its occurrence is unrelated to other indices of liver function, such as laboratory values, viral load, and genotype. In the present review, evidence outlining the presence of cognitive deficits associated with HCV, possible etiological factors, effects of antiviral therapy, and co-infection with human immunodeficiency virus (HIV) is presented. Implications of these findings and directions for future work are discussed.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.