ReviewNature reviews. Genetics2007
Integrating physical and genetic maps: from genomes to interaction networks.
Review in Nature reviews. Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring drug-target interaction networks of illicit drugs.BMC genomics · 2013Pooled it
- Protein-protein interactions are a major source of epistasis in genetic interaction networks.Nature communications · 2026Article
- Computational Systems Biology Approaches to Cellular Aging - Integrating Network Maps and Dynamical Models.Quantitative biology (Beijing, China) · 2025Article
- Discovery of paradoxical genes: reevaluating the prognostic impact of overexpressed genes in cancer.Frontiers in cell and developmental biology · 2025Review
- Gene regulatory networks in disease and ageing.Nature reviews. Nephrology · 2024Review
- Integration of probabilistic functional networks without an external Gold Standard.BMC bioinformatics · 2022Article
- Quantitative Genetic Screens for Mapping Bacterial Pathways and Functional Networks.Methods in molecular biology (Clifton, N.J.) · 2021Article
- BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells.Nature structural & molecular biology · 2020Article
- ce-Subpathway: Identification of ceRNA-mediated subpathways via joint power of ceRNAs and pathway topologies.Journal of cellular and molecular medicine · 2019Article
- PanoromiX: a time-course network medicine platform integrating molecular assays and pathophenotypic data.BMC bioinformatics · 2018Article
- Testing the Domino Theory of Gene Loss inLife (Basel, Switzerland) · 2018Article
- Integrative network analyses of wilt transcriptome in chickpea reveal genotype dependent regulatory hubs in immunity and susceptibility.Scientific reports · 2018Article
- One for all and all for One: Improving replication of genetic studies through network diffusion.PLoS genetics · 2018Article
- Application of CRISPR-Cas9 Based Genome-Wide Screening Approaches to Study Cellular Signalling Mechanisms.International journal of molecular sciences · 2018Review
- Detection of COPB2 as a KRAS synthetic lethal partner through integration of functional genomics screens.Oncotarget · 2017Article
- SpidermiR: An R/Bioconductor Package for Integrative Analysis with miRNA Data.International journal of molecular sciences · 2017Article
- Gene Mining for Proline Based Signaling Proteins in Cell Wall ofFrontiers in plant science · 2017Review
- Integrative analysis of cancer genes in a functional interactome.Scientific reports · 2016Article
- Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines.Cell reports · 2016Article
- Predicting chemotherapeutic drug combinations through gene network profiling.Scientific reports · 2016Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Physical and genetic mapping data have become as important to network biology as they once were to the Human Genome Project. Integrating physical and genetic networks currently faces several challenges: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. A particular challenge involves reconciling the wide variety of interaction types that are currently available. For this purpose, recent studies have sought to classify genetic and physical interactions along several complementary dimensions, such as ordered versus unordered, alleviating versus aggravating, and first versus second degree.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.