ReviewNature reviews. Genetics2007
Mechanistic approaches to the study of evolution: the functional synthesis.
Review in Nature reviews. Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
181 citing papers in PubMed, 364 citations in OpenAlex.
- Structural ontogeny of protein-protein interactions.Science (New York, N.Y.) · 2026Article
- Gene function predicts divergence across molecular levels.bioRxiv : the preprint server for biology · 2026Article
- The neural substrates of behavioral evolution: Divergent behaviors from conserved neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolutionary paths that link orthogonal pairs of binding proteins.Cell systems · 2025Article
- Article
- Yerba mate (eLife · 2025Article
- Plasticity and environment-specific relationships between gene expression and fitness in Saccharomyces cerevisiae.Nature ecology & evolution · 2024Article
- Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction.Nature communications · 2024Article
- Review
- Article
- Plasticity and environment-specific relationships between gene expression and fitness inbioRxiv : the preprint server for biology · 2024Article
- Extant Sequence Reconstruction: The Accuracy of Ancestral Sequence Reconstructions Evaluated by Extant Sequence Cross-Validation.Journal of molecular evolution · 2024Article
- Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades.bioRxiv : the preprint server for biology · 2023Article
- Structural evolution of an immune evasion determinant shapes pathogen host tropism.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Interdisciplinary approaches to predicting evolutionary biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Contributions of mutation and selection to regulatory variation: lessons from thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Ancestrally Reconstructed von Willebrand Factor Reveals Evidence for Trench Warfare Coevolution between Opossums and Pit Vipers.Molecular biology and evolution · 2022Article
- Evidence of multiple genome duplication events in Mytilus evolution.BMC genomics · 2022Article
- Evolution in small steps and giant leaps.Evolution; international journal of organic evolution · 2022Review
121 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
An emerging synthesis of evolutionary biology and experimental molecular biology is providing much stronger and deeper inferences about the dynamics and mechanisms of evolution than were possible in the past. The new approach combines statistical analyses of gene sequences with manipulative molecular experiments to reveal how ancient mutations altered biochemical processes and produced novel phenotypes. This functional synthesis has set the stage for major advances in our understanding of fundamental questions in evolutionary biology. Here we describe this emerging approach, highlight important new insights that it has made possible, and suggest future directions for the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.